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C16orf89 chromosome 16 open reading frame 89 [ Homo sapiens (human) ]

Gene ID: 146556, updated on 21-May-2020

Summary

Official Symbol
C16orf89provided by HGNC
Official Full Name
chromosome 16 open reading frame 89provided by HGNC
Primary source
HGNC:HGNC:28687
See related
Ensembl:ENSG00000153446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is expressed predominantly in the thyroid. Based on expression patterns similar to thyroid transcription factors and proteins, this gene may function in the development and function of the thyroid. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in thyroid (RPKM 83.5), lung (RPKM 41.7) and 7 other tissues See more
Orthologs

Genomic context

See C16orf89 in Genome Data Viewer
Location:
16p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (5042772..5066145, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (5092925..5116146, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SEC14 like lipid binding 5 Neighboring gene NAGPA antisense RNA 1 Neighboring gene N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase Neighboring gene uncharacterized LOC107984828 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45438

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030316.1 RefSeqGene

    Range
    5001..27024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098514.3NP_001091984.2  UPF0764 protein C16orf89 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001091984.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC026458
    Consensus CDS
    CCDS45404.2
    UniProtKB/Swiss-Prot
    Q6UX73
    Related
    ENSP00000420566.2, ENST00000472572.7
    Conserved Domains (1) summary
    pfam15882
    Location:60340
    DUF4735; Domain of unknown function (DUF4735)
  2. NM_152459.4NP_689672.4  UPF0764 protein C16orf89 isoform 1 precursor

    See identical proteins and their annotated locations for NP_689672.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC026458, AK075242, AY358483, BC033681
    Consensus CDS
    CCDS42116.2
    UniProtKB/Swiss-Prot
    Q6UX73
    Related
    ENSP00000324672.5, ENST00000315997.5
    Conserved Domains (2) summary
    pfam13900
    Location:323370
    GVQW; Putative domain of unknown function
    pfam15882
    Location:60319
    DUF4735; Domain of unknown function (DUF4735)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    5042772..5066145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255143.3XP_005255200.2  UPF0764 protein C16orf89 isoform X2

    Conserved Domains (1) summary
    pfam15882
    Location:60318
    DUF4735; Domain of unknown function (DUF4735)
  2. XM_017022974.1XP_016878463.1  UPF0764 protein C16orf89 isoform X1

  3. XM_017022972.1XP_016878461.1  UPF0764 protein C16orf89 isoform X1

  4. XM_011522392.2XP_011520694.1  UPF0764 protein C16orf89 isoform X3

    Conserved Domains (2) summary
    pfam13900
    Location:137184
    GVQW; Putative domain of unknown function
    pfam15882
    Location:1133
    DUF4735; Domain of unknown function (DUF4735)
  5. XM_017022973.1XP_016878462.1  UPF0764 protein C16orf89 isoform X1

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