U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF688 zinc finger protein 688 [ Homo sapiens (human) ]

Gene ID: 146542, updated on 17-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF688provided by HGNC
Official Full Name
zinc finger protein 688provided by HGNC
Primary source
HGNC:HGNC:30489
See related
Ensembl:ENSG00000229809 AllianceGenome:HGNC:30489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.3), fat (RPKM 3.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF688 in Genome Data Viewer
Location:
16p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30569726..30579951, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30956705..30967326, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30581047..30583728, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30564727-30565226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30568583-30569144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10714 Neighboring gene zinc finger protein 764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30580811-30581376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30581377-30581940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7379 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30596216-30596816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30597418-30598018 Neighboring gene zinc finger protein 785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene proline rich 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
  3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  4. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  5. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR, et al. Biochem J, 2016 Oct 15. PMID 27503909, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 688 (ZNF688) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 688

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024683.2 → NP_001019854.1  zinc finger protein 688 isoform b

    See identical proteins and their annotated locations for NP_001019854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK122680, BC018997, BM011208
    Consensus CDS
    CCDS42151.1
    UniProtKB/Swiss-Prot
    P0C7X2
    Related
    ENSP00000455227.2, ENST00000563276.5
    Conserved Domains (4) summary
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169 → 191
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:184 → 208
    zf-H2C2_2; Zinc-finger double domain
    cl00993
    Location:128 → 196
    Zn-ribbon_8; Zinc ribbon domain

  2. NM_145271.4 → NP_660314.1  zinc finger protein 688 isoform a

    See identical proteins and their annotated locations for NP_660314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AK122680, BC018997
    Consensus CDS
    CCDS10684.1
    UniProtKB/Swiss-Prot
    A8MV39, B3KV51, O75701, P0C7X2, Q8IW91, Q8WV14, Q96MN0
    UniProtKB/TrEMBL
    A0A0S2Z633
    Related
    ENSP00000223459.6, ENST00000223459.11
    Conserved Domains (4) summary
    smart00349
    Location:26 → 86
    KRAB; krueppel associated box
    sd00017
    Location:185 → 205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:183 → 205
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:198 → 222
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30569726..30579951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433654.1 → XP_047289610.1  zinc finger protein 688 isoform X2

  2. XM_047433653.1 → XP_047289609.1  zinc finger protein 688 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5X4

  3. XM_005255140.3 → XP_005255197.1  zinc finger protein 688 isoform X3

    See identical proteins and their annotated locations for XP_005255197.1

    Conserved Domains (5) summary
    COG5048
    Location:82 → 158
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108 → 128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:106 → 128
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:121 → 145
    zf-H2C2_2; Zinc-finger double domain
    cl00993
    Location:65 → 133
    Zn-ribbon_8; Zinc ribbon domain

  4. XM_005255139.3 → XP_005255196.1  zinc finger protein 688 isoform X3

    See identical proteins and their annotated locations for XP_005255196.1

    Conserved Domains (5) summary
    COG5048
    Location:82 → 158
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108 → 128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:106 → 128
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:121 → 145
    zf-H2C2_2; Zinc-finger double domain
    cl00993
    Location:65 → 133
    Zn-ribbon_8; Zinc ribbon domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30956705..30967326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379679.1 → XP_054235654.1  zinc finger protein 688 isoform X4

  2. XM_054379681.1 → XP_054235656.1  zinc finger protein 688 isoform X2

  3. XM_054379680.1 → XP_054235655.1  zinc finger protein 688 isoform X5

  4. XM_054379682.1 → XP_054235657.1  zinc finger protein 688 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7X2.1 GenPept UniProtKB/Swiss-Prot:P0C7X2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous