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ZNF688 zinc finger protein 688 [ Homo sapiens (human) ]

Gene ID: 146542, updated on 8-Dec-2022

Summary

Official Symbol
ZNF688provided by HGNC
Official Full Name
zinc finger protein 688provided by HGNC
Primary source
HGNC:HGNC:30489
See related
Ensembl:ENSG00000229809 AllianceGenome:HGNC:30489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.3), fat (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF688 in Genome Data Viewer
Location:
16p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30569726..30579951, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30956705..30959386, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30581047..30583728, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903677 Neighboring gene zinc finger protein 764 Neighboring gene zinc finger protein 785 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene proline rich 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 688 (ZNF688) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024683.2NP_001019854.1  zinc finger protein 688 isoform b

    See identical proteins and their annotated locations for NP_001019854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK122680, BC018997, BM011208
    Consensus CDS
    CCDS42151.1
    UniProtKB/Swiss-Prot
    P0C7X2
    Related
    ENSP00000455227.2, ENST00000563276.5
    Conserved Domains (4) summary
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169191
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:184208
    zf-H2C2_2; Zinc-finger double domain
    cl00993
    Location:128196
    Zn-ribbon_8; Zinc ribbon domain
  2. NM_145271.4NP_660314.1  zinc finger protein 688 isoform a

    See identical proteins and their annotated locations for NP_660314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AK122680, BC018997
    Consensus CDS
    CCDS10684.1
    UniProtKB/Swiss-Prot
    P0C7X2, Q96MN0
    UniProtKB/TrEMBL
    A0A0S2Z633
    Related
    ENSP00000223459.6, ENST00000223459.11
    Conserved Domains (4) summary
    smart00349
    Location:2686
    KRAB; krueppel associated box
    sd00017
    Location:185205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:183205
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:198222
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30569726..30579951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433654.1XP_047289610.1  zinc finger protein 688 isoform X2

  2. XM_047433653.1XP_047289609.1  zinc finger protein 688 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z5X4
  3. XM_005255140.3XP_005255197.1  zinc finger protein 688 isoform X3

    See identical proteins and their annotated locations for XP_005255197.1

    UniProtKB/TrEMBL
    A0A024QZB6
    Conserved Domains (5) summary
    COG5048
    Location:82158
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:106128
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:121145
    zf-H2C2_2; Zinc-finger double domain
    cl00993
    Location:65133
    Zn-ribbon_8; Zinc ribbon domain
  4. XM_005255139.3XP_005255196.1  zinc finger protein 688 isoform X3

    See identical proteins and their annotated locations for XP_005255196.1

    UniProtKB/TrEMBL
    A0A024QZB6
    Conserved Domains (5) summary
    COG5048
    Location:82158
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:106128
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:121145
    zf-H2C2_2; Zinc-finger double domain
    cl00993
    Location:65133
    Zn-ribbon_8; Zinc ribbon domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30956705..30959386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)