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ZNF785 zinc finger protein 785 [ Homo sapiens (human) ]

Gene ID: 146540, updated on 11-Jun-2021

Summary

Official Symbol
ZNF785provided by HGNC
Official Full Name
zinc finger protein 785provided by HGNC
Primary source
HGNC:HGNC:26496
See related
Ensembl:ENSG00000197162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF688
Expression
Ubiquitous expression in endometrium (RPKM 2.1), ovary (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF785 in Genome Data Viewer
Location:
16p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30572939..30586038, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30591977..30597018, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 764 Neighboring gene zinc finger protein 688 Neighboring gene zinc finger protein 689 Neighboring gene proline rich 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 785 (ZNF785) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32130

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 785
Names
Zinc finger protein 688

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152458.7NP_689671.2  zinc finger protein 785

    See identical proteins and their annotated locations for NP_689671.2

    Status: VALIDATED

    Source sequence(s)
    AC002310, BC040642, CN401082
    Consensus CDS
    CCDS10685.1
    UniProtKB/Swiss-Prot
    A8K8V0
    UniProtKB/TrEMBL
    A0A024QZC7
    Related
    ENSP00000378642.2, ENST00000395216.3
    Conserved Domains (3) summary
    smart00349
    Location:2989
    KRAB; krueppel associated box
    COG5048
    Location:143359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174194
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30572939..30586038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450163.1XP_024305931.1  zinc finger protein 785 isoform X1

  2. XM_024450164.1XP_024305932.1  zinc finger protein 785 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:2989
    KRAB; krueppel associated box
    COG5048
    Location:143359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174194
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_011545753.2XP_011544055.1  zinc finger protein 785 isoform X1

    See identical proteins and their annotated locations for XP_011544055.1

    Conserved Domains (6) summary
    smart00349
    Location:29102
    KRAB; krueppel associated box
    COG5048
    Location:156372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:185207
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2968
    KRAB; KRAB box
    pfam13465
    Location:312336
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017022967.2XP_016878456.1  zinc finger protein 785 isoform X2

    UniProtKB/Swiss-Prot
    A8K8V0
    UniProtKB/TrEMBL
    A0A024QZC7
    Related
    ENSP00000420340.1, ENST00000470110.2
    Conserved Domains (3) summary
    smart00349
    Location:2989
    KRAB; krueppel associated box
    COG5048
    Location:143359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174194
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_011545752.2XP_011544054.1  zinc finger protein 785 isoform X1

    See identical proteins and their annotated locations for XP_011544054.1

    Conserved Domains (6) summary
    smart00349
    Location:29102
    KRAB; krueppel associated box
    COG5048
    Location:156372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:185207
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2968
    KRAB; KRAB box
    pfam13465
    Location:312336
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_002957780.1 RNA Sequence

  2. XR_001751844.2 RNA Sequence

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