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Glra1 glycine receptor, alpha 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 14654, updated on 2-Jul-2024

Summary

Official Symbol
Glra1provided by MGI
Official Full Name
glycine receptor, alpha 1 subunitprovided by MGI
Primary source
MGI:MGI:95747
See related
Ensembl:ENSMUSG00000000263 AllianceGenome:MGI:95747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ot; spd; nmf11; spasmodic; oscillator
Summary
Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in glycinergic synaptic transmission; inhibitory postsynaptic potential; and response to alcohol. Acts upstream of or within several processes, including adult walking behavior; regulation of respiratory gaseous exchange by nervous system process; and righting reflex. Located in several cellular components, including external side of plasma membrane; glycinergic synapse; and inhibitory synapse. Is expressed in brain; brainstem; and spinal cord. Used to study hyperekplexia and hyperekplexia 1. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.8), CNS E11.5 (RPKM 0.5) and 1 other tissue See more
Orthologs
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Genomic context

See Glra1 in Genome Data Viewer
Location:
11 B1.3; 11 33.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55405065..55499024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55514239..55608198, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12238 Neighboring gene G3BP stress granule assembly factor 1 Neighboring gene microRNA 7652 Neighboring gene predicted gene 12236 Neighboring gene STARR-seq mESC enhancer starr_29547 Neighboring gene STARR-seq mESC enhancer starr_29550 Neighboring gene STARR-seq mESC enhancer starr_29551 Neighboring gene STARR-seq mESC enhancer starr_29552 Neighboring gene STARR-seq mESC enhancer starr_29553 Neighboring gene predicted gene, 50502 Neighboring gene STARR-seq mESC enhancer starr_29554 Neighboring gene predicted gene 12239 Neighboring gene STARR-seq mESC enhancer starr_29558 Neighboring gene neuromedin U receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 
  • Spontaneous (5)  1 citation
  • Targeted (6)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • B230397M16Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellularly glycine-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellularly glycine-gated chloride channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to extracellularly glycine-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly glycine-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly glycine-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glycine binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables taurine binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling posture IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of acrosome reaction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to alcohol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within righting reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within startle response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission, glycinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission, glycinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission, glycinergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glycinergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in inhibitory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glycine receptor subunit alpha-1
Names
glycine receptor 48 kDa subunit
glycine receptor strychnine-binding subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290821.1NP_001277750.1  glycine receptor subunit alpha-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001277750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK078258, AL596207, AY129229
    Consensus CDS
    CCDS70190.1
    UniProtKB/Swiss-Prot
    Q5NCT8, Q64018, Q64019, Q9R0Y6, Q9R0Y7
    Related
    ENSMUSP00000075032.5, ENSMUST00000075603.5
    Conserved Domains (1) summary
    TIGR00860
    Location:7446
    LIC; Cation transporter family protein
  2. NM_020492.4NP_065238.2  glycine receptor subunit alpha-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_065238.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK078258, AL596207, AY129229
    Consensus CDS
    CCDS24715.1
    UniProtKB/TrEMBL
    Q5NCT9
    Related
    ENSMUSP00000099777.4, ENSMUST00000102716.10
    Conserved Domains (1) summary
    TIGR00860
    Location:7438
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55405065..55499024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)