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Hagh hydroxyacyl glutathione hydrolase [ Mus musculus (house mouse) ]

Gene ID: 14651, updated on 31-Jan-2019

Summary

Official Symbol
Haghprovided by MGI
Official Full Name
hydroxyacyl glutathione hydrolaseprovided by MGI
Primary source
MGI:MGI:95745
See related
Ensembl:ENSMUSG00000024158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glo2; Glo-2; Rsp29; BC019817
Expression
Ubiquitous expression in liver adult (RPKM 156.6), kidney adult (RPKM 107.1) and 25 other tissues See more
Orthologs

Genomic context

See Hagh in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (24840079..24864450)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24987435..25001395)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6 Neighboring gene meiosis specific with OB domains Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydroxyacylglutathione hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydroxyacylglutathione hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glutathione biosynthetic process IC
Inferred by Curator
more info
PubMed 
glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 

General protein information

Preferred Names
hydroxyacylglutathione hydrolase, mitochondrial
Names
glx II
glyoxalase II
glyoxylase 2
round spermatid protein RSP29
NP_001153098.1
NP_077246.2
XP_006523723.1
XP_006523724.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159626.1NP_001153098.1  hydroxyacylglutathione hydrolase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001153098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and CDS, and uses a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1 and is a cytosolic protein.
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50021.1
    UniProtKB/Swiss-Prot
    Q99KB8
    UniProtKB/TrEMBL
    A0A0R4J052
    Related
    ENSMUSP00000024974.9, ENSMUST00000024974.15
    Conserved Domains (3) summary
    PLN02469
    Location:1256
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:174254
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:6173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
  2. NM_024284.2NP_077246.2  hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_077246.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1) which is localized to the mitochondria.
    Source sequence(s)
    AK147022, BQ128470, BY348635
    Consensus CDS
    CCDS28499.2
    UniProtKB/Swiss-Prot
    Q99KB8
    UniProtKB/TrEMBL
    G5E8T9
    Related
    ENSMUSP00000113051.1, ENSMUST00000118788.7
    Conserved Domains (3) summary
    PLN02469
    Location:50305
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:223303
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:55222
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    24840079..24864450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523661.1XP_006523724.1  hydroxyacylglutathione hydrolase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006523724.1

    UniProtKB/Swiss-Prot
    Q99KB8
    UniProtKB/TrEMBL
    A0A0R4J052
    Related
    ENSMUSP00000129904.1, ENSMUST00000164251.7
    Conserved Domains (3) summary
    PLN02469
    Location:1256
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:174254
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:6173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
  2. XM_006523660.2XP_006523723.1  hydroxyacylglutathione hydrolase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006523723.1

    UniProtKB/Swiss-Prot
    Q99KB8
    UniProtKB/TrEMBL
    A0A0R4J052
    Conserved Domains (3) summary
    PLN02469
    Location:1256
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:174254
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:6173
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
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