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CSRP1 cysteine and glycine rich protein 1 [ Homo sapiens (human) ]

Gene ID: 1465, updated on 15-Apr-2019

Summary

Official Symbol
CSRP1provided by HGNC
Official Full Name
cysteine and glycine rich protein 1provided by HGNC
Primary source
HGNC:HGNC:2469
See related
Ensembl:ENSG00000159176 MIM:123876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141; HEL-S-286
Summary
This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Expression
Broad expression in prostate (RPKM 425.1), endometrium (RPKM 406.6) and 22 other tissues See more
Orthologs

Genomic context

See CSRP1 in Genome Data Viewer
Location:
1q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (201483530..201507259, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201452658..201476387, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929367 Neighboring gene pleckstrin homology like domain family A member 3 Neighboring gene uncharacterized LOC107985246 Neighboring gene ribosomal protein S10 pseudogene 7 Neighboring gene neuron navigator 1 Neighboring gene IPO9 antisense RNA 1 Neighboring gene microRNA 5191

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
    MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
platelet aggregation HMP PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cysteine and glycine-rich protein 1
Names
LIM-domain protein
cysteine-rich protein 1
epididymis luminal protein 141
epididymis secretory protein Li 286
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193570.1NP_001180499.1  cysteine and glycine-rich protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001180499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC096677, AK302237, AW163500, BC032493
    UniProtKB/Swiss-Prot
    P21291
    UniProtKB/TrEMBL
    B4DY28
    Conserved Domains (2) summary
    cd09479
    Location:863
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)
    cl02475
    Location:119166
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001193571.1NP_001180500.1  cysteine and glycine-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001180500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC096677, AK290133, BC032493
    Consensus CDS
    CCDS1413.1
    UniProtKB/Swiss-Prot
    P21291
    Related
    ENSP00000436792.1, ENST00000533432.5
    Conserved Domains (2) summary
    cd09403
    Location:119172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:863
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)
  3. NM_001193572.1NP_001180501.1  cysteine and glycine-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001180501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC096677, AK293053, BC032493
    Consensus CDS
    CCDS1413.1
    UniProtKB/Swiss-Prot
    P21291
    Related
    ENSP00000434147.1, ENST00000532460.5
    Conserved Domains (2) summary
    cd09403
    Location:119172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:863
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)
  4. NM_004078.3NP_004069.1  cysteine and glycine-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AW163500, BC032493, CA411857, CF453919
    Consensus CDS
    CCDS1413.1
    UniProtKB/Swiss-Prot
    P21291
    Related
    ENSP00000345079.2, ENST00000340006.7
    Conserved Domains (2) summary
    cd09403
    Location:119172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:863
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    201483530..201507259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001144773.1: Suppressed sequence

    Description
    NM_001144773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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