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TMED6 transmembrane p24 trafficking protein 6 [ Homo sapiens (human) ]

Gene ID: 146456, updated on 5-Jan-2022

Summary

Official Symbol
TMED6provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 6provided by HGNC
Primary source
HGNC:HGNC:28331
See related
Ensembl:ENSG00000157315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p24g5; PRO34237; SPLL9146
Summary
Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in pancreas (RPKM 31.6), stomach (RPKM 12.4) and 4 other tissues See more
Orthologs
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Genomic context

See TMED6 in Genome Data Viewer
Location:
16q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (69343250..69351786, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69377153..69385689, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 4 homolog A Neighboring gene component of oligomeric golgi complex 8 Neighboring gene peptide deformylase, mitochondrial Neighboring gene nucleolar pre-rRNA processing protein NIP7 Neighboring gene telomeric repeat binding factor 2 Neighboring gene cytochrome b5 type B Neighboring gene transmembrane protein 111 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23911

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane emp24 domain-containing protein 6
Names
p24 family protein gamma-5
p24gamma5
transmembrane emp24 protein transport domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144676.4NP_653277.2  transmembrane emp24 domain-containing protein 6 precursor

    See identical proteins and their annotated locations for NP_653277.2

    Status: VALIDATED

    Source sequence(s)
    AA804957, AY358268, BC020827, BI600655
    Consensus CDS
    CCDS10878.1
    UniProtKB/Swiss-Prot
    Q8WW62
    Related
    ENSP00000288025.3, ENST00000288025.4
    Conserved Domains (1) summary
    pfam01105
    Location:43228
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    69343250..69351786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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