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ZNF597 zinc finger protein 597 [ Homo sapiens (human) ]

Gene ID: 146434, updated on 23-Nov-2021

Summary

Official Symbol
ZNF597provided by HGNC
Official Full Name
zinc finger protein 597provided by HGNC
Primary source
HGNC:HGNC:26573
See related
Ensembl:ENSG00000167981 MIM:614685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIT-4
Summary
This gene encodes a protein with multiple zinc finger domains. Loss of the related gene in rodents results in defects in neural development and embryonic lethality in mutant homozygotes. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in testis (RPKM 3.2), lung (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF597 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3432414..3443504, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3482414..3493504, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene zinc finger and SCAN domain containing 32 Neighboring gene zinc finger protein 174 Neighboring gene N-alpha-acetyltransferase 60, NatF catalytic subunit Neighboring gene Sharpr-MPRA regulatory region 11363 Neighboring gene microRNA 6126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_045222.1 RefSeqGene

    Range
    5034..16124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1066

mRNA and Protein(s)

  1. NM_152457.3NP_689670.1  zinc finger protein 597

    See identical proteins and their annotated locations for NP_689670.1

    Status: REVIEWED

    Source sequence(s)
    AC025283, AI038687, AL701654
    Consensus CDS
    CCDS10505.1
    UniProtKB/Swiss-Prot
    Q96LX8
    Related
    ENSP00000301744.4, ENST00000301744.7
    Conserved Domains (3) summary
    COG5048
    Location:150422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:158178
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3432414..3443504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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