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IL34 interleukin 34 [ Homo sapiens (human) ]

Gene ID: 146433, updated on 6-Sep-2021

Summary

Official Symbol
IL34provided by HGNC
Official Full Name
interleukin 34provided by HGNC
Primary source
HGNC:HGNC:28529
See related
Ensembl:ENSG00000157368 MIM:612081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-34; C16orf77
Summary
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Expression
Biased expression in spleen (RPKM 59.9), skin (RPKM 16.8) and 5 other tissues See more
Orthologs
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Genomic context

See IL34 in Genome Data Viewer
Location:
16q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70579899..70660682)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70613802..70694585)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene splicing factor 3b subunit 3 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene MTSS I-BAR domain containing 2 Neighboring gene VAC14 component of PIKFYVE complex Neighboring gene VAC14 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34647

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables macrophage colony-stimulating factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables macrophage colony-stimulating factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-34-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of macrophage proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of monocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172771.2NP_001166242.1  interleukin-34 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001166242.1

    Status: VALIDATED

    Source sequence(s)
    AK172744, AW292500, BQ709387, CD515627, EU599219
    UniProtKB/Swiss-Prot
    Q6ZMJ4
    Conserved Domains (1) summary
    pfam15036
    Location:28183
    IL34; Interleukin 34
  2. NM_001172772.2NP_001166243.1  interleukin-34 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001166243.1

    Status: VALIDATED

    Source sequence(s)
    AC020763, AK172744, AW292500, CD248375
    Consensus CDS
    CCDS10895.1
    UniProtKB/Swiss-Prot
    Q6ZMJ4
    UniProtKB/TrEMBL
    A0A024QZ87
    Conserved Domains (1) summary
    pfam15036
    Location:28184
    IL34; Interleukin 34
  3. NM_001393493.1NP_001380422.1  interleukin-34 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020763, AC106804
    Conserved Domains (1) summary
    pfam15036
    Location:28184
    IL34; Interleukin 34
  4. NM_001393494.1NP_001380423.1  interleukin-34 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020763
    Related
    ENSP00000288098.2, ENST00000288098.6
    Conserved Domains (1) summary
    pfam15036
    Location:28184
    IL34; Interleukin 34
  5. NM_001393495.1NP_001380424.1  interleukin-34 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020763, AC106804
    Conserved Domains (1) summary
    pfam15036
    Location:28183
    IL34; Interleukin 34
  6. NM_001393496.1NP_001380425.1  interleukin-34 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020763
    Conserved Domains (1) summary
    pfam15036
    Location:28183
    IL34; Interleukin 34
  7. NM_001393497.1NP_001380426.1  interleukin-34 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC020763
    Related
    ENSP00000463886.1, ENST00000566361.1
    Conserved Domains (1) summary
    pfam15036
    Location:3159
    IL34; Interleukin 34
  8. NM_001393498.1NP_001380427.1  interleukin-34 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC020763
    Conserved Domains (1) summary
    pfam15036
    Location:3158
    IL34; Interleukin 34
  9. NM_152456.3NP_689669.2  interleukin-34 isoform 1 precursor

    See identical proteins and their annotated locations for NP_689669.2

    Status: VALIDATED

    Source sequence(s)
    AK172744, AW292500, BQ709387
    Consensus CDS
    CCDS10895.1
    UniProtKB/Swiss-Prot
    Q6ZMJ4
    UniProtKB/TrEMBL
    A0A024QZ87
    Related
    ENSP00000397863.2, ENST00000429149.6
    Conserved Domains (1) summary
    pfam15036
    Location:28184
    IL34; Interleukin 34

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70579899..70660682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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