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Galk1 galactokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 14635, updated on 5-Feb-2023

Summary

Official Symbol
Galk1provided by MGI
Official Full Name
galactokinase 1provided by MGI
Primary source
MGI:MGI:95730
See related
Ensembl:ENSMUSG00000020766 AllianceGenome:MGI:95730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gk; Glk; GALK; Glk1
Summary
Enables galactokinase activity. Acts upstream of or within galactitol metabolic process and glycolytic process from galactose. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cataract and galactokinase deficiency. Orthologous to human GALK1 (galactokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 109.7), liver E18 (RPKM 50.3) and 24 other tissues See more
Orthologs
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Genomic context

See Galk1 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115899183..115903545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116008357..116012719, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4 Neighboring gene H3.3 histone B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables galactokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables galactokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables galactokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables galactose binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
galactokinase
Names
galactose kinase
NP_058601.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016905.2NP_058601.2  galactokinase

    See identical proteins and their annotated locations for NP_058601.2

    Status: VALIDATED

    Source sequence(s)
    AK011103, AK045694, BB771442
    Consensus CDS
    CCDS25654.1
    UniProtKB/Swiss-Prot
    Q9JIA6, Q9R0N0
    UniProtKB/TrEMBL
    A0A8C6I8P7, Q9CXZ9
    Related
    ENSMUSP00000021114.5, ENSMUST00000021114.5
    Conserved Domains (4) summary
    PRK05101
    Location:12390
    PRK05101; galactokinase; Provisional
    pfam00288
    Location:128193
    GHMP_kinases_N; GHMP kinases N terminal domain
    pfam08544
    Location:291372
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:1967
    GalKase_gal_bdg; Galactokinase galactose-binding signature

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115899183..115903545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)