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FBXL16 F-box and leucine rich repeat protein 16 [ Homo sapiens (human) ]

Gene ID: 146330, updated on 9-Sep-2018

Summary

Official Symbol
FBXL16provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 16provided by HGNC
Primary source
HGNC:HGNC:14150
See related
Ensembl:ENSG00000127585 MIM:609082; Vega:OTTHUMG00000090420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbl16; C16orf22; c380A1.1
Summary
Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 76.4), testis (RPKM 4.8) and 1 other tissue See more
Orthologs

Genomic context

See FBXL16 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (692500..707853, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (742500..755825, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene jumonji domain containing 8 Neighboring gene WD repeat domain 24 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene family with sequence similarity 173 member A Neighboring gene coiled-coil domain containing 78

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ33735, MGC33974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/LRR-repeat protein 16
Names
c380A1.1 (novel protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153350.3NP_699181.2  F-box/LRR-repeat protein 16

    See identical proteins and their annotated locations for NP_699181.2

    Status: VALIDATED

    Source sequence(s)
    Z92544, Z97653
    Consensus CDS
    CCDS10421.1
    UniProtKB/Swiss-Prot
    Q8N461
    Related
    ENSP00000380746.1, OTTHUMP00000115487, ENST00000397621.5, OTTHUMT00000206851
    Conserved Domains (2) summary
    sd00034
    Location:220243
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:201413
    AMN1; Antagonist of mitotic exit network protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    692500..707853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450160.1XP_024305928.1  F-box/LRR-repeat protein 16 isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:220243
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:201413
    AMN1; Antagonist of mitotic exit network protein 1
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