Gli1 GLI-Kruppel family member GLI1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gli1provided by MGI
Official Full Name: GLI-Kruppel family member GLI1provided by MGI
Primary source: MGI:MGI:95727
See related: Ensembl:ENSMUSG00000025407 AllianceGenome:MGI:95727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp5; Zfp-5
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in positive regulation of DNA-templated transcription and regulation of osteoblast differentiation. Acts upstream of or within several processes, including central nervous system development; liver regeneration; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Human ortholog(s) of this gene implicated in gallbladder cancer and preaxial polydactyly I. Orthologous to human GLI1 (GLI family zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in limb E14.5 (RPKM 44.9), subcutaneous fat pad adult (RPKM 27.9) and 14 other tissues See more
Orthologs: all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127165751..127177448, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127329882..127341579, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor-derived GLI1 promotes remodeling of the immune tumor microenvironment in melanoma.
Title: Tumor-derived GLI1 promotes remodeling of the immune tumor microenvironment in melanoma.
GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases.
Title: GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases.
FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3beta/GLI1 pathway.
Title: FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway.
The effects of Gli1 and Gli2 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.
Title: The effects of Gli1 and Gli2 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.
The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
Title: The SHH-GLI1 pathway is required in skin expansion and angiogenesis.
The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis.
Title: The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis.
Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting ppargamma expression.
Title: Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression.
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling.
Title: A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling.
GLI transcriptional repression is inert prior to Hedgehog pathway activation.
Title: GLI transcriptional repression is inert prior to Hedgehog pathway activation.
Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
Title: Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.

Submit: New GeneRIF Correction See all GeneRIFs (99)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU043488 (e-PCR)
- UniSTS:160050

Gli (e-PCR), detects polymorphism
- UniSTS:238132

UniSTS:465478 (e-PCR)
- UniSTS:465478

Gli1 (e-PCR), detects polymorphism
- UniSTS:465478

Gli1 (e-PCR), detects polymorphism
- UniSTS:495952

Gli1 (e-PCR), detects polymorphism
- UniSTS:496738

UniSTS:259693 (e-PCR)
- UniSTS:259693

Gli1 (e-PCR), detects polymorphism
- UniSTS:259693

NoName (e-PCR)
- UniSTS:548487

AF026305 (e-PCR)
- UniSTS:163490

Gli1 (e-PCR), detects polymorphism
- UniSTS:528039

AV235269 (e-PCR)
- UniSTS:180136

Gli1 (e-PCR), detects polymorphism
- UniSTS:548066

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellar cortex morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic organ morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epidermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
involved_in gland development	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within notochord regression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pituitary gland development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in prostate gland development	IEA Inferred from Electronic Annotation more info
involved_in proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ventral midline development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of GLI-SUFU complex	IEA Inferred from Electronic Annotation more info
part_of GLI-SUFU complex	ISO Inferred from Sequence Orthology more info
part_of axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary tip	IEA Inferred from Electronic Annotation more info
located_in ciliary tip	ISO Inferred from Sequence Orthology more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription activator GLI1

Names: glioma-associated oncogene homolog; zinc finger protein 5; zinc finger protein GLI1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010296.2 → NP_034426.2 transcription activator GLI1

See identical proteins and their annotated locations for NP_034426.2

Status: VALIDATED

Source sequence(s)

AC114678, AF026305, CF898732, CJ062804, CV782971

Consensus CDS

CCDS24238.1

UniProtKB/Swiss-Prot

G5E857, P47806, Q9QYK1

UniProtKB/TrEMBL

A2RRI7

Related

ENSMUSP00000026474.4, ENSMUST00000026474.6

Conserved Domains (4) summary

COG5236
Location:196 → 438

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:306 → 328

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:320 → 347

zf-H2C2_2; Zinc-finger double domain

pfam16159
Location:240 → 268

FOXP-CC; FOXP coiled-coil domain