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CMTM2 CKLF like MARVEL transmembrane domain containing 2 [ Homo sapiens (human) ]

Gene ID: 146225, updated on 24-Feb-2019

Summary

Official Symbol
CMTM2provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 2provided by HGNC
Primary source
HGNC:HGNC:19173
See related
Ensembl:ENSG00000140932 MIM:607885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLFSF2
Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 259.5) See more
Orthologs

Genomic context

See CMTM2 in Genome Data Viewer
Location:
16q21
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (66579448..66588275)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66613351..66622178)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF-CMTM1 readthrough Neighboring gene chemokine like factor Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 4 Neighboring gene CKLF like MARVEL transmembrane domain containing 3 Neighboring gene putative uncharacterized protein encoded by LINC00269

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) inhibits HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppression of HIV-1 provirus transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC39436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 2
Names
chemokine-like factor superfamily 2
chemokine-like factor superfamily member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199317.1NP_001186246.1  CKLF-like MARVEL transmembrane domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001186246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AY862139
    Consensus CDS
    CCDS56001.1
    UniProtKB/Swiss-Prot
    Q8TAZ6
    Related
    ENSP00000368800.2, ENST00000379486.6
    Conserved Domains (1) summary
    cl24062
    Location:70139
    Phage_holin_3_3; LydA holin phage, holin superfamily III
  2. NM_144673.3NP_653274.1  CKLF-like MARVEL transmembrane domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_653274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC025354
    Consensus CDS
    CCDS10814.1
    UniProtKB/Swiss-Prot
    Q8TAZ6
    Related
    ENSP00000268595.2, ENST00000268595.2
    Conserved Domains (1) summary
    pfam01284
    Location:82198
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    66579448..66588275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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