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VWA3A von Willebrand factor A domain containing 3A [ Homo sapiens (human) ]

Gene ID: 146177, updated on 4-Oct-2020

Summary

Official Symbol
VWA3Aprovided by HGNC
Official Full Name
von Willebrand factor A domain containing 3Aprovided by HGNC
Primary source
HGNC:HGNC:27088
See related
Ensembl:ENSG00000175267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lung (RPKM 3.4), testis (RPKM 1.7) and 2 other tissues See more
Orthologs

Genomic context

See VWA3A in Genome Data Viewer
Location:
16p12.2
Exon count:
39
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (22091929..22156966)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22019462..22168287)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 9 Neighboring gene islet cell autoantigen 1, 69kDa pseudogene Neighboring gene modulator of smoothened Neighboring gene uncharacterized LOC105371129 Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene tRNA-Leu (anticodon TAG) 3-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40941, FLJ46765

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
von Willebrand factor A domain-containing protein 3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034015.1 RefSeqGene

    Range
    5004..69427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173615.5NP_775886.3  von Willebrand factor A domain-containing protein 3A precursor

    See identical proteins and their annotated locations for NP_775886.3

    Status: VALIDATED

    Source sequence(s)
    AC009019, AK307544, BC038400, BC109295, DA102773, DA240074
    Consensus CDS
    CCDS45441.1
    UniProtKB/Swiss-Prot
    A6NCI4
    Related
    ENSP00000374049.5, ENST00000389398.10
    Conserved Domains (2) summary
    pfam13768
    Location:169324
    VWA_3; von Willebrand factor type A domain
    cl00057
    Location:9631109
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    22091929..22156966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545742.3XP_011544044.1  von Willebrand factor A domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_011544044.1

    Conserved Domains (2) summary
    pfam13768
    Location:187342
    VWA_3; von Willebrand factor type A domain
    cl00057
    Location:10261172
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. XM_017022947.1XP_016878436.1  von Willebrand factor A domain-containing protein 3A isoform X1

    Conserved Domains (2) summary
    pfam13768
    Location:187342
    VWA_3; von Willebrand factor type A domain
    cl00057
    Location:10261172
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. XM_024450158.1XP_024305926.1  von Willebrand factor A domain-containing protein 3A isoform X2

    Conserved Domains (2) summary
    pfam13768
    Location:1131
    VWA_3; von Willebrand factor type A domain
    cl00057
    Location:815961
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  4. XM_011545744.2XP_011544046.1  von Willebrand factor A domain-containing protein 3A isoform X3

    Conserved Domains (1) summary
    cl00057
    Location:530676
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. XM_011545746.2XP_011544048.1  von Willebrand factor A domain-containing protein 3A isoform X5

    Conserved Domains (1) summary
    cl00057
    Location:487633
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  6. XM_017022948.1XP_016878437.1  von Willebrand factor A domain-containing protein 3A isoform X3

    Conserved Domains (1) summary
    cl00057
    Location:530676
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  7. XM_017022949.1XP_016878438.1  von Willebrand factor A domain-containing protein 3A isoform X6

  8. XM_011545745.1XP_011544047.1  von Willebrand factor A domain-containing protein 3A isoform X4

    Conserved Domains (1) summary
    cl00057
    Location:502648
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    948074..1012497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175059.2: Suppressed sequence

    Description
    NM_175059.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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