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HEVBgp1 genome polyportein [ Enterovirus B ]

Gene ID: 1461114, updated on 18-Aug-2023
Gene symbol
HEVBgp1
Gene description
genome polyportein
Locus tag
HEVBgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Enterovirus B
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Picornavirales; Picornaviridae; Ensavirinae; Enterovirus
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Location:
clone: pCV(B1)EE[1,2,3,4]; pCV(B1)KE1; pCV(B1)PP[1,2]
Sequence:
NC_001472.1 (742..7290)

NC_001472.1Genomic Context describing neighboring genes Neighboring gene miscRNA

Genomic Sequence:
NC_001472.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
    Title: SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
  2. Data suggest that protease 2A of CVB3 exhibits substrate specificity that includes human/mouse NFAT5 in cardiomyocytes; NFAT5 inhibits CVB3 replication via mechanism that involves iNOS; anti-CVB3 activity of NFAT5 is impaired during CVB3 infection due to protease 2A-mediated cleavage of NFAT5. (CVB3 = Coxsackievirus 3; NFAT5 = tonicity-responsive nuclear factor of activated T-cells 5; iNOS = nitric oxide synthase type II)
    Title: Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication.
  3. study reports the molecular impact of the 3C protease T68A/N126Y double mutant (Mutant(Bound)) using an integrated computational approach
    Title: Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease.
  4. MDA5 and MAVS cleavages are both mediated by coxsackievirus B3 2A protease.
    Title: Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
  5. Using reverse genetics, a single amino acid change within the exposed region of the VP1 protein (glutamine to lysine at position 164) was identified as the determinant for the acquired cytolytic trait.
    Title: A single coxsackievirus B2 capsid residue controls cytolysis and apoptosis in rhabdomyosarcoma cells.
  6. findings show that show that 3A mutants that have lost the ability to dimerize are no longer able to bind to GBF1 and trap it on membranes; data provide insight into the molecular requirements of the interaction between 3A and GBF1
    Title: Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1.
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Preferred Names
genome polyportein
Names
1A(VP4)
1B(VP2)
1C(VP3)
1D(VP1)
protease 2A
protein 2B
protein 2C
protien 3A
3B(VPg)
protease 3C
3D

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001472.1 Reference assembly

    Range
    742..7290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040958.1 genome polyportein [Enterovirus B]

    See identical proteins and their annotated locations for NP_040958.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08291
    UniProtKB/TrEMBL
    A8DB69
    Conserved Domains (8) summary
    pfam00548
    Location:1538 → 1703
    Peptidase_C3; 3C cysteine protease (picornain 3C)
    pfam01552
    Location:998 → 1097
    Pico_P2B; Picornavirus 2B protein
    pfam02226
    Location:2 → 69
    Pico_P1A; Picornavirus coat protein (VP4)
    pfam00073
    Location:93 → 301
    Rhv; picornavirus capsid protein
    pfam00910
    Location:1222 → 1320
    RNA_helicase; RNA helicase
    pfam00947
    Location:867 → 993
    Pico_P2A; Picornavirus core protein 2A
    pfam08727
    Location:1423 → 1473
    P3A; Poliovirus 3A protein like
    cl02808
    Location:1737 → 2180
    RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...

  2. NP_740537.1 1A(VP4)

    UniProtKB/TrEMBL
    F5BZJ3, Q3V6G9, Q3V6H6, Q3V6I0, Q3V6I8, Q4LF11, Q4LF13, Q4LG56, Q4LG57, Q8QWF0, Q8QWF7, Q8QWF8, Q99ID4
    Conserved Domains (1) summary
    pfam02226
    Location:2 → 69
    Pico_P1A; Picornavirus coat protein (VP4)

  3. NP_740538.1 1B(VP2)

    Conserved Domains (1) summary
    pfam00073
    Location:24 → 233
    Rhv; picornavirus capsid protein

  4. NP_740539.1 1C(VP3)

    Conserved Domains (1) summary
    pfam00073
    Location:28 → 194
    Rhv; picornavirus capsid protein

  5. NP_740540.1 1D(VP1)

    UniProtKB/TrEMBL
    A0A0H5AVN1, H2CVU5, H2CVU8, H2CVU9, H2CVV2
    Conserved Domains (1) summary
    pfam00073
    Location:44 → 212
    Rhv; picornavirus capsid protein

  6. NP_740541.1 protease 2A

    Conserved Domains (1) summary
    pfam00947
    Location:19 → 145
    Pico_P2A; Picornavirus core protein 2A

  7. NP_740542.1 protein 2B

    UniProtKB/TrEMBL
    K4N8L7
    Conserved Domains (1) summary
    pfam01552
    Location:1 → 99
    Pico_P2B; Picornavirus 2B protein

  8. NP_740543.1 protein 2C

    Conserved Domains (2) summary
    smart00382
    Location:124 → 251
    AAA; ATPases associated with a variety of cellular activities
    pfam00910
    Location:125 → 223
    RNA_helicase; RNA helicase

  9. NP_740544.1 protien 3A

    UniProtKB/TrEMBL
    A0A1X9RU15
    Conserved Domains (1) summary
    pfam08727
    Location:1 → 61
    P3A; Poliovirus 3A protein like

  10. NP_740545.1 3B(VPg)

  11. NP_740546.1 protease 3C

    UniProtKB/Swiss-Prot
    P08490
    Conserved Domains (1) summary
    pfam00548
    Location:1 → 166
    Peptidase_C3; 3C cysteine protease (picornain 3C)

  12. NP_740547.1 3D

    Conserved Domains (1) summary
    cl02808
    Location:17 → 460
    RT_like; RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
Protein Accession Links
GenPept Link UniProtKB Link
AAC00531.1

Gene LinkOut

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