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Gpr83 G protein-coupled receptor 83 [ Mus musculus (house mouse) ]

Gene ID: 14608, updated on 24-Jan-2023

Summary

Official Symbol
Gpr83provided by MGI
Official Full Name
G protein-coupled receptor 83provided by MGI
Primary source
MGI:MGI:95712
See related
Ensembl:ENSMUSG00000031932 AllianceGenome:MGI:95712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gir; RP39; RP82; Gpr72; RP105
Summary
Predicted to enable neuropeptide receptor activity. Acts upstream of or within response to glucocorticoid. Located in non-motile cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and pectoralis. Orthologous to human GPR83 (G protein-coupled receptor 83). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.8), frontal lobe adult (RPKM 3.6) and 11 other tissues See more
Orthologs
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Genomic context

See Gpr83 in Genome Data Viewer
Location:
9 A2; 9 4.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14771038..14782085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14859880..14870789)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MRE11A homolog A, double strand break repair nuclease Neighboring gene macrophage migration inhibitory factor, pseudogene 6 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene coenzyme Q10 homolog B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 83; probable G-protein coupled receptor 83
Names
glucocorticoid-induced receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310734.1NP_001297663.1  G-protein coupled receptor 83 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC136743, AK030359, AK035356, AK041527
    Consensus CDS
    CCDS80959.1
    UniProtKB/TrEMBL
    Q544C4
    Related
    ENSMUSP00000111287.3, ENSMUST00000115624.3
    Conserved Domains (1) summary
    pfam00001
    Location:88303
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_010287.3NP_034417.1  G-protein coupled receptor 83 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030359, AK035356, AK041527, AK081276
    Consensus CDS
    CCDS22829.1
    UniProtKB/Swiss-Prot
    P30731, Q544C4
    UniProtKB/TrEMBL
    Q542Q9, Q544C4
    Related
    ENSMUSP00000034408.6, ENSMUST00000034408.12
    Conserved Domains (2) summary
    pfam00001
    Location:88345
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:78225
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14771038..14782085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244058.2XP_030099918.1  probable G-protein coupled receptor 83 isoform X1

    Conserved Domains (1) summary
    cd15389
    Location:72413
    7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_006510017.4XP_006510080.1  probable G-protein coupled receptor 83 isoform X2

    UniProtKB/Swiss-Prot
    P30731
    Conserved Domains (1) summary
    cd15389
    Location:72376
    7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors