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Ghrhr growth hormone releasing hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 14602, updated on 5-Mar-2024

Summary

Official Symbol
Ghrhrprovided by MGI
Official Full Name
growth hormone releasing hormone receptorprovided by MGI
Primary source
MGI:MGI:95710
See related
Ensembl:ENSMUSG00000004654 AllianceGenome:MGI:95710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lit; Ghrfr; little
Summary
Enables growth hormone-releasing hormone receptor activity and peptide hormone binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including gland development; positive regulation of growth hormone secretion; and regulation of signal transduction. Located in plasma membrane. Is integral component of membrane. Is expressed in alimentary system; brain; metanephros; and spinal cord. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Orthologous to human GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
6 B3; 6 27.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55353204..55365515)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55376295..55388530)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38819 Neighboring gene aquaporin 1 Neighboring gene RIKEN cDNA 6430584L05 gene Neighboring gene adenylate cyclase activating polypeptide 1 receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth hormone-releasing hormone receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables growth hormone-releasing hormone receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth hormone-releasing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of intracellular steroid hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somatotropin secreting cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth hormone-releasing hormone receptor
Names
GHRH receptor
GRF receptor
GRFR
growth hormone-releasing factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003685.3NP_001003685.2  growth hormone-releasing hormone receptor precursor

    See identical proteins and their annotated locations for NP_001003685.2

    Status: VALIDATED

    Source sequence(s)
    AC083946, AK030504, BB027246, BB618094
    Consensus CDS
    CCDS20165.1
    UniProtKB/Swiss-Prot
    P32082, Q0VB62
    Related
    ENSMUSP00000068120.4, ENSMUST00000063578.6
    Conserved Domains (2) summary
    pfam00002
    Location:126372
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:53112
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55353204..55365515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165843.1XP_036021736.1  growth hormone-releasing hormone receptor isoform X1

    Conserved Domains (3) summary
    pfam02793
    Location:53112
    HRM; Hormone receptor domain
    cd14964
    Location:128153
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:126325
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily