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Ghrhr growth hormone releasing hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 14602, updated on 18-Sep-2018

Summary

Official Symbol
Ghrhrprovided by MGI
Official Full Name
growth hormone releasing hormone receptorprovided by MGI
Primary source
MGI:MGI:95710
See related
Ensembl:ENSMUSG00000004654 Vega:OTTMUSG00000057887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lit; Ghrfr; little
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Ghrhr in Genome Data Viewer
Location:
6 B3; 6 27.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (55376295..55388530)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (55326289..55338524)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38819 Neighboring gene aquaporin 1 Neighboring gene RIKEN cDNA 6430584L05 gene Neighboring gene adenylate cyclase activating polypeptide 1 receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
growth hormone-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth hormone-releasing hormone receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
growth hormone-releasing hormone receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone-releasing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
positive regulation of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular steroid hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
somatotropin secreting cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
water homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth hormone-releasing hormone receptor
Names
GHRH receptor
GRF receptor
GRFR
growth hormone-releasing factor receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003685.3NP_001003685.2  growth hormone-releasing hormone receptor precursor

    See identical proteins and their annotated locations for NP_001003685.2

    Status: VALIDATED

    Source sequence(s)
    AC083946, AK030504, BB027246, BB618094
    Consensus CDS
    CCDS20165.1
    UniProtKB/Swiss-Prot
    P32082
    Related
    ENSMUSP00000068120.3, OTTMUSP00000074204, ENSMUST00000063578.5, OTTMUST00000142147
    Conserved Domains (2) summary
    pfam00002
    Location:126372
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:53112
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    55376295..55388530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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