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ADRA1D adrenoceptor alpha 1D [ Homo sapiens (human) ]

Gene ID: 146, updated on 4-Jun-2020

Summary

Official Symbol
ADRA1Dprovided by HGNC
Official Full Name
adrenoceptor alpha 1Dprovided by HGNC
Primary source
HGNC:HGNC:280
See related
Ensembl:ENSG00000171873 MIM:104219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues See more
Orthologs

Genomic context

See ADRA1D in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (4220630..4249287, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (4201278..4229659, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene spermine oxidase Neighboring gene long intergenic non-protein coding RNA 1433 Neighboring gene uncharacterized LOC105372510 Neighboring gene ribosomal protein L7a pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha1-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of heart rate by epinephrine-norepinephrine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-1D adrenergic receptor
Names
adrenergic, alpha -1D-, receptor
adrenergic, alpha-1A-, receptor
alpha-1A adrenergic receptor
alpha-1D adrenoceptor
alpha-1D adrenoreceptor
alpha-adrenergic receptor 1a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000678.4NP_000669.1  alpha-1D adrenergic receptor

    See identical proteins and their annotated locations for NP_000669.1

    Status: REVIEWED

    Source sequence(s)
    AL121675, AL357040, S70782, U03864
    Consensus CDS
    CCDS13079.1
    UniProtKB/Swiss-Prot
    P25100
    UniProtKB/TrEMBL
    B0ZBE0
    Related
    ENSP00000368766.4, ENST00000379453.6
    Conserved Domains (1) summary
    cd15327
    Location:97413
    7tmA_alpha1D_AR; alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    4220630..4249287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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