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NRG4 neuregulin 4 [ Homo sapiens (human) ]

Gene ID: 145957, updated on 21-Dec-2019

Summary

Official Symbol
NRG4provided by HGNC
Official Full Name
neuregulin 4provided by HGNC
Primary source
HGNC:HGNC:29862
See related
Ensembl:ENSG00000169752 MIM:610894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRG4
Summary
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 2.0), skin (RPKM 1.9) and 25 other tissues See more
Orthologs

Genomic context

See NRG4 in Genome Data Viewer
Location:
15q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75933219..76069830, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76234314..76304785, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8353 Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene RNA, 7SL, cytoplasmic 510, pseudogene Neighboring gene F-box protein 22 Neighboring gene transmembrane protein 266 Neighboring gene uncharacterized LOC101929439 Neighboring gene electron transfer flavoprotein subunit alpha Neighboring gene TYRO3P protein tyrosine kinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779N0541, DKFZp779N1944

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
regulation of cell motility TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pro-neuregulin-4, membrane-bound isoform
Names
heregulin 4
pro-NRG4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138573.4NP_612640.1  pro-neuregulin-4, membrane-bound isoform

    See identical proteins and their annotated locations for NP_612640.1

    Status: VALIDATED

    Source sequence(s)
    AC027104, BC017568
    Consensus CDS
    CCDS10288.1
    UniProtKB/Swiss-Prot
    Q8WWG1
    Related
    ENSP00000378367.3, ENST00000394907.8
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75933219..76069830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021947.2XP_016877436.1  pro-neuregulin-4, membrane-bound isoform isoform X3

    UniProtKB/Swiss-Prot
    Q8WWG1
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  2. XM_017021946.2XP_016877435.1  pro-neuregulin-4, membrane-bound isoform isoform X3

    UniProtKB/Swiss-Prot
    Q8WWG1
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  3. XM_017021948.2XP_016877437.1  pro-neuregulin-4, membrane-bound isoform isoform X3

    UniProtKB/Swiss-Prot
    Q8WWG1
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  4. XM_024449848.1XP_024305616.1  pro-neuregulin-4, membrane-bound isoform isoform X3

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  5. XM_017021945.2XP_016877434.1  pro-neuregulin-4, membrane-bound isoform isoform X3

    UniProtKB/Swiss-Prot
    Q8WWG1
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  6. XM_024449847.1XP_024305615.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  7. XM_017021939.2XP_016877428.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  8. XM_017021938.2XP_016877427.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  9. XM_017021940.2XP_016877429.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  10. XM_017021944.2XP_016877433.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    Related
    ENSP00000455167.1, ENST00000563910.5
  11. XM_017021937.2XP_016877426.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  12. XM_017021942.2XP_016877431.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  13. XM_017021941.2XP_016877430.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  14. XM_017021943.2XP_016877432.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
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