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NRG4 neuregulin 4 [ Homo sapiens (human) ]

Gene ID: 145957, updated on 17-Sep-2024

Summary

Official Symbol
NRG4provided by HGNC
Official Full Name
neuregulin 4provided by HGNC
Primary source
HGNC:HGNC:29862
See related
Ensembl:ENSG00000169752 MIM:610894; AllianceGenome:HGNC:29862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRG4
Summary
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 2.0), skin (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

See NRG4 in Genome Data Viewer
Location:
15q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75935393..76060240, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73806132..73930956, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76233277..76304765, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76084438-76084938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76084939-76085439 Neighboring gene dynamin 1 pseudogene 49 Neighboring gene Sharpr-MPRA regulatory region 8353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76135870-76136767 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76163679-76164628 Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:76195387-76196046 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76196047-76196704 Neighboring gene RNA, 7SL, cytoplasmic 510, pseudogene Neighboring gene F-box protein 22 Neighboring gene uncharacterized LOC124903616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76311273-76311774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6687 Neighboring gene transmembrane protein 266 Neighboring gene uncharacterized LOC124903531 Neighboring gene Sharpr-MPRA regulatory region 3592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76432149-76432982 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:76442422-76442685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76442959-76443537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:76444006-76444636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76453363-76454200 Neighboring gene uncharacterized LOC101929439

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp779N0541, DKFZp779N1944

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ERBB4-ERBB4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pro-neuregulin-4, membrane-bound isoform
Names
heregulin 4
pro-NRG4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138573.4NP_612640.1  pro-neuregulin-4, membrane-bound isoform

    See identical proteins and their annotated locations for NP_612640.1

    Status: VALIDATED

    Source sequence(s)
    AC027104, BC017568
    Consensus CDS
    CCDS10288.1
    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
    Related
    ENSP00000378367.3, ENST00000394907.8
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    75935393..76060240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432183.1XP_047288139.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  2. XM_047432182.1XP_047288138.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
    Related
    ENSP00000455167.1, ENST00000563910.5
  3. XM_047432181.1XP_047288137.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  4. XM_047432184.1XP_047288140.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  5. XM_047432178.1XP_047288134.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  6. XM_047432179.1XP_047288135.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  7. XM_047432180.1XP_047288136.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  8. XM_017021948.3XP_016877437.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  9. XM_024449848.2XP_024305616.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
    Related
    ENSP00000457335.1, ENST00000566417.5
    Conserved Domains (1) summary
    cl28647
    Location:983
    PHA02887; EGF-like protein; Provisional
  10. XM_047432185.1XP_047288141.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
  11. XM_047432186.1XP_047288142.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63

RNA

  1. XR_007064433.1 RNA Sequence

  2. XR_007064432.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    73806132..73930956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377346.1XP_054233321.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  2. XM_054377345.1XP_054233320.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  3. XM_054377344.1XP_054233319.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  4. XM_054377347.1XP_054233322.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  5. XM_054377342.1XP_054233317.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  6. XM_054377343.1XP_054233318.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  7. XM_054377341.1XP_054233316.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    H3BP63
  8. XM_054377351.1XP_054233326.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
  9. XM_054377350.1XP_054233325.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
  10. XM_054377348.1XP_054233323.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63
  11. XM_054377349.1XP_054233324.1  pro-neuregulin-4, membrane-bound isoform isoform X2

    UniProtKB/Swiss-Prot
    A6NIE8, Q8WWG1
    UniProtKB/TrEMBL
    H3BP63

RNA

  1. XR_008488924.1 RNA Sequence

  2. XR_008488923.1 RNA Sequence