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PGPEP1L pyroglutamyl-peptidase I like [ Homo sapiens (human) ]

Gene ID: 145814, updated on 24-Sep-2022

Summary

Official Symbol
PGPEP1Lprovided by HGNC
Official Full Name
pyroglutamyl-peptidase I likeprovided by HGNC
Primary source
HGNC:HGNC:27080
See related
Ensembl:ENSG00000183571 AllianceGenome:HGNC:27080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable pyroglutamyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PGPEP1L in Genome Data Viewer
Location:
15q26.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (98968229..99007792, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (96732626..96772141, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (99511458..99551021, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 1 receptor Neighboring gene microRNA 4714 Neighboring gene uncharacterized LOC124903561 Neighboring gene leukemia-associated non-coding IGF1R activator RNA 1 Neighboring gene SYNM antisense RNA 1 Neighboring gene synemin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pyroglutamyl-peptidase 1-like protein
NP_001096082.2
NP_001161374.1
XP_011519556.1
XP_016877422.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102612.2NP_001096082.2  pyroglutamyl-peptidase 1-like protein isoform 1

    See identical proteins and their annotated locations for NP_001096082.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the allele encoded by the GRCh38 reference genome and encodes isoform 1.
    Source sequence(s)
    AC036108, AK058162, BC104743, BC104744
    Consensus CDS
    CCDS53977.1
    UniProtKB/Swiss-Prot
    A6NFU8, H0YF86
    Related
    ENSP00000368199.6, ENST00000378919.6
    Conserved Domains (1) summary
    cl00237
    Location:8152
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
  2. NM_001167902.2NP_001161374.1  pyroglutamyl-peptidase 1-like protein isoform 2

    See identical proteins and their annotated locations for NP_001161374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It also represents the allele encoded by the GRCh38 reference genome. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC036108, AC069029, AK058162, BC104743, BC104744
    Consensus CDS
    CCDS58400.1
    UniProtKB/Swiss-Prot
    A6NFU8
    Related
    ENSP00000437560.1, ENST00000535714.2
    Conserved Domains (1) summary
    cl00237
    Location:598
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
  3. NM_001412129.1NP_001399058.1  pyroglutamyl-peptidase 1-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses the same exon combination as variant 2 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (3) has a frameshifted C-terminus compared to isoform 2.
    Source sequence(s)
    CP068263
  4. NM_001412130.1NP_001399059.1  pyroglutamyl-peptidase 1-like protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (4) has a frameshifted C-terminus compared to isoform 1.
    Source sequence(s)
    CP068263

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    98968229..99007792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521254.2XP_011519556.1  pyroglutamyl-peptidase 1-like protein isoform X1

    Conserved Domains (1) summary
    cd00501
    Location:76243
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
  2. XM_017021933.2XP_016877422.1  pyroglutamyl-peptidase 1-like protein isoform X2

    UniProtKB/Swiss-Prot
    A6NFU8
    Conserved Domains (1) summary
    cl00237
    Location:598
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    96732626..96772141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)