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Gem GTP binding protein overexpressed in skeletal muscle [ Mus musculus (house mouse) ]

Gene ID: 14579, updated on 12-May-2024

Summary

Official Symbol
Gemprovided by MGI
Official Full Name
GTP binding protein overexpressed in skeletal muscleprovided by MGI
Primary source
MGI:MGI:99844
See related
Ensembl:ENSMUSG00000028214 AllianceGenome:MGI:99844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including calcium channel regulator activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to be involved in chromosome organization; metaphase plate congression; and mitotic cell cycle. Located in nucleus. Is expressed in several structures, including clavicle; dorsal grey horn; gut; telencephalon ventricular layer; and tooth. Orthologous to human GEM (GTP binding protein overexpressed in skeletal muscle). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 36.0), lung adult (RPKM 14.1) and 16 other tissues See more
Orthologs
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Genomic context

See Gem in Genome Data Viewer
Location:
4 A1; 4 5.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11702379..11714993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11704447..11714993)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09604 Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene predicted gene, 35884 Neighboring gene STARR-positive B cell enhancer ABC_E2103 Neighboring gene VISTA enhancer mm1633 Neighboring gene cadherin 17 Neighboring gene STARR-seq mESC enhancer starr_09605 Neighboring gene STARR-seq mESC enhancer starr_09606 Neighboring gene predicted gene, 54235

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
GTP-binding protein GEM
Names
GTP binding protein (gene overexpressed in skeletal muscle)
GTP-binding mitogen-induced T-cell protein
RAS-like protein KIR
NP_034406.2
XP_036019576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010276.4NP_034406.2  GTP-binding protein GEM

    See identical proteins and their annotated locations for NP_034406.2

    Status: VALIDATED

    Source sequence(s)
    AK158393, AK168401, BY574090
    Consensus CDS
    CCDS17971.1
    UniProtKB/Swiss-Prot
    P55041, Q8JZS1
    UniProtKB/TrEMBL
    Q3TH76
    Related
    ENSMUSP00000103939.3, ENSMUST00000108304.9
    Conserved Domains (2) summary
    smart00010
    Location:75241
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:75295
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11702379..11714993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163683.1XP_036019576.1  GTP-binding protein GEM isoform X1

    Conserved Domains (1) summary
    cd04148
    Location:75281
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases