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Gdnf glial cell line derived neurotrophic factor [ Mus musculus (house mouse) ]

Gene ID: 14573, updated on 12-Aug-2018

Summary

Official Symbol
Gdnfprovided by MGI
Official Full Name
glial cell line derived neurotrophic factorprovided by MGI
Primary source
MGI:MGI:107430
See related
Ensembl:ENSMUSG00000022144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATF; AI385739
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Expression
Broad expression in lung adult (RPKM 1.6), ovary adult (RPKM 1.5) and 19 other tissues See more
Orthologs

Genomic context

See Gdnf in Genome Data Viewer
Location:
15; 15 A1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (7810048..7837580)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (7761011..7787575)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41264 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 pseudogene Neighboring gene transcription factor BTF3 pseudogene Neighboring gene WD repeat domain 70 Neighboring gene ribosomal protein L19, pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
glial cell-derived neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
commissural neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
enteric nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
organ induction IGI
Inferred from Genetic Interaction
more info
PubMed 
peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
postganglionic parasympathetic fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic membrane organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of morphogenesis of a branching structure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
ureteric bud development IDA
Inferred from Direct Assay
more info
PubMed 
ureteric bud development IGI
Inferred from Genetic Interaction
more info
PubMed 
ureteric bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glial cell line-derived neurotrophic factor
Names
astrocyte-derived trophic factor
neurotrophic factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301332.1NP_001288261.1  glial cell line-derived neurotrophic factor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC130656, CJ061678, CJ093961, U75532
    UniProtKB/Swiss-Prot
    P48540
    Conserved Domains (1) summary
    pfam00019
    Location:119213
    TGF_beta; Transforming growth factor beta like domain
  2. NM_001301333.1NP_001288262.1  glial cell line-derived neurotrophic factor isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130656
    Conserved Domains (1) summary
    pfam00019
    Location:136230
    TGF_beta; Transforming growth factor beta like domain
  3. NM_001301357.1NP_001288286.1  glial cell line-derived neurotrophic factor isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_001288286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130656
    UniProtKB/Swiss-Prot
    P48540
    Conserved Domains (1) summary
    pfam00019
    Location:116210
    TGF_beta; Transforming growth factor beta like domain
  4. NM_010275.3NP_034405.1  glial cell line-derived neurotrophic factor isoform 1

    See identical proteins and their annotated locations for NP_034405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC130656, CJ061678, CJ093961, D88264
    Consensus CDS
    CCDS27371.1
    UniProtKB/Swiss-Prot
    P48540
    Related
    ENSMUSP00000022744.3, ENSMUST00000022744.4
    Conserved Domains (1) summary
    pfam00019
    Location:145239
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    7810048..7837580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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