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Gdnf glial cell line derived neurotrophic factor [ Mus musculus (house mouse) ]

Gene ID: 14573, updated on 17-Jan-2023

Summary

Official Symbol
Gdnfprovided by MGI
Official Full Name
glial cell line derived neurotrophic factorprovided by MGI
Primary source
MGI:MGI:107430
See related
Ensembl:ENSMUSG00000022144 AllianceGenome:MGI:107430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATF
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Expression
Broad expression in lung adult (RPKM 1.6), ovary adult (RPKM 1.5) and 19 other tissues See more
Orthologs
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Genomic context

See Gdnf in Genome Data Viewer
Location:
15; 15 A1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (7839529..7867061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (7810048..7837580)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41264 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 pseudogene Neighboring gene basic transcription factor 3, pseudogene 16 Neighboring gene WD repeat domain 70 Neighboring gene ribosomal protein L19, pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in commissural neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dorsal spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in enteric nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neural crest cell migration involved in autonomic nervous system development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organ induction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
involved_in postganglionic parasympathetic fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within postsynaptic membrane organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of morphogenesis of a branching structure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ureteric bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glial cell line-derived neurotrophic factor
Names
astrocyte-derived trophic factor
neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301332.1NP_001288261.1  glial cell line-derived neurotrophic factor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC130656, CJ061678, CJ093961, U75532
    UniProtKB/Swiss-Prot
    P48540
    UniProtKB/TrEMBL
    A0A8C6HZP9
    Conserved Domains (1) summary
    pfam00019
    Location:119213
    TGF_beta; Transforming growth factor beta like domain
  2. NM_001301333.1NP_001288262.1  glial cell line-derived neurotrophic factor isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130656
    Conserved Domains (1) summary
    pfam00019
    Location:136230
    TGF_beta; Transforming growth factor beta like domain
  3. NM_001301357.1NP_001288286.1  glial cell line-derived neurotrophic factor isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_001288286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130656
    UniProtKB/Swiss-Prot
    P48540, Q6LEL9
    Conserved Domains (1) summary
    pfam00019
    Location:116210
    TGF_beta; Transforming growth factor beta like domain
  4. NM_010275.3NP_034405.1  glial cell line-derived neurotrophic factor isoform 1

    See identical proteins and their annotated locations for NP_034405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC130656, CJ061678, CJ093961, D88264
    Consensus CDS
    CCDS27371.1
    UniProtKB/Swiss-Prot
    P48540
    Related
    ENSMUSP00000022744.4, ENSMUST00000022744.5
    Conserved Domains (1) summary
    pfam00019
    Location:145239
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    7839529..7867061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)