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CSNK1G3 casein kinase 1 gamma 3 [ Homo sapiens (human) ]

Gene ID: 1456, updated on 5-Apr-2020

Summary

Official Symbol
CSNK1G3provided by HGNC
Official Full Name
casein kinase 1 gamma 3provided by HGNC
Primary source
HGNC:HGNC:2456
See related
Ensembl:ENSG00000151292 MIM:604253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNK1G3L; CKI-gamma 3
Summary
This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in colon (RPKM 8.2), small intestine (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See CSNK1G3 in Genome Data Viewer
Location:
5q23.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (123512099..123617049)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (122847793..122952739)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene centrosomal protein 120 Neighboring gene keratin 8 pseudogene 33 Neighboring gene high mobility group box 3 pseudogene 17 Neighboring gene keratin 18 pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC101927397

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein casein kinase 1, gamma 3 (CSNK1G3) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
casein kinase I isoform gamma-3; casein kinase I
NP_001026982.1
NP_001038188.1
NP_001257501.1
NP_001257502.1
NP_001257503.1
NP_001351069.1
NP_001351070.1
NP_001351072.1
NP_001351073.1
NP_001351074.1
NP_001351075.1
NP_001351076.1
NP_001351077.1
NP_001351078.1
NP_001351079.1
NP_004375.2
XP_005271949.1
XP_005271951.1
XP_005271952.1
XP_016864546.1
XP_016864548.1
XP_016864549.1
XP_016864550.1
XP_016864551.1
XP_016864552.1
XP_016864553.1
XP_016864554.1
XP_016864556.1
XP_016864557.1
XP_016864558.1
XP_016864559.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031812.3NP_001026982.1  casein kinase I isoform gamma-3 isoform 2

    See identical proteins and their annotated locations for NP_001026982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC008541, AF049089, BC047567, BX116822, DA409424
    Consensus CDS
    CCDS34218.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000334735.4, ENST00000345990.8
    Conserved Domains (2) summary
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328374
    CK1gamma_C; Casein kinase 1 gamma C terminal
  2. NM_001044723.2NP_001038188.1  casein kinase I isoform gamma-3 isoform 4

    See identical proteins and their annotated locations for NP_001038188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as CSNK1G3L) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC008541, AF049090, BC047567, BX116822
    Consensus CDS
    CCDS43355.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000353904.2, ENST00000360683.6
    Conserved Domains (2) summary
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328406
    CK1gamma_C; Casein kinase 1 gamma C terminal
  3. NM_001270572.1NP_001257501.1  casein kinase I isoform gamma-3 isoform 5

    See identical proteins and their annotated locations for NP_001257501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC008541, AK289405, BC047567, BX116822
    Consensus CDS
    CCDS59491.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000423838.2, ENST00000510842.6
    Conserved Domains (2) summary
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329375
    CK1gamma_C; Casein kinase 1 gamma C terminal
  4. NM_001270573.2NP_001257502.1  casein kinase I isoform gamma-3 isoform 6

    See identical proteins and their annotated locations for NP_001257502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
    Source sequence(s)
    AC008541, AK299739, BX116822, DA409424
    Consensus CDS
    CCDS59492.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000421998.3, ENST00000512718.7
    Conserved Domains (2) summary
    pfam12605
    Location:253299
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1253
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001270574.2NP_001257503.1  casein kinase I isoform gamma-3 isoform 7

    See identical proteins and their annotated locations for NP_001257503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008541, AK316019, BX116822, DA409424
    Consensus CDS
    CCDS59493.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000421385.2, ENST00000511130.6
    Conserved Domains (2) summary
    pfam12605
    Location:216262
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1216
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001364140.2NP_001351069.1  casein kinase I isoform gamma-3 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (8) is 1 aa longer compared to isoform 1 and is the longest isoform.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329407
    CK1gamma_C; Casein kinase 1 gamma C terminal
  7. NM_001364141.2NP_001351070.1  casein kinase I isoform gamma-3 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    cd14126
    Location:42353
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:353399
    CK1gamma_C; Casein kinase 1 gamma C terminal
  8. NM_001364143.2NP_001351072.1  casein kinase I isoform gamma-3 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame splice junction and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329375
    CK1gamma_C; Casein kinase 1 gamma C terminal
  9. NM_001364144.2NP_001351073.1  casein kinase I isoform gamma-3 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (11) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:253331
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1253
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001364145.2NP_001351074.1  casein kinase I isoform gamma-3 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (12) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:254300
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1254
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001364146.2NP_001351075.1  casein kinase I isoform gamma-3 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (13) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:215293
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001364147.2NP_001351076.1  casein kinase I isoform gamma-3 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (14) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:215261
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  13. NM_001364148.2NP_001351077.1  casein kinase I isoform gamma-3 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (15) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:215261
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  14. NM_001364149.2NP_001351078.1  casein kinase I isoform gamma-3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:253299
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1253
    PKc_like; Protein Kinases, catalytic domain
  15. NM_001364150.2NP_001351079.1  casein kinase I isoform gamma-3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 6, 16, and 17 all encode the same isoform (6).
    Source sequence(s)
    AC008541, AC026422
    Conserved Domains (2) summary
    pfam12605
    Location:253299
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1253
    PKc_like; Protein Kinases, catalytic domain
  16. NM_004384.4NP_004375.2  casein kinase I isoform gamma-3 isoform 1

    See identical proteins and their annotated locations for NP_004375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC008541, AF049089, BC047567, BX116822
    Consensus CDS
    CCDS4135.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000354942.2, ENST00000361991.6
    Conserved Domains (2) summary
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328406
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    123512099..123617049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009060.1XP_016864549.1  casein kinase I isoform X1

  2. XM_017009059.1XP_016864548.1  casein kinase I isoform X1

  3. XM_017009069.1XP_016864558.1  casein kinase I isoform X11

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329375
    CK1gamma_C; Casein kinase 1 gamma C terminal
  4. XM_017009057.2XP_016864546.1  casein kinase I isoform X1

  5. XM_017009063.2XP_016864552.1  casein kinase I isoform X3

  6. XM_017009064.2XP_016864553.1  casein kinase I isoform X6

  7. XM_017009067.2XP_016864556.1  casein kinase I isoform X9

  8. XM_017009061.2XP_016864550.1  casein kinase I isoform X2

  9. XM_017009065.2XP_016864554.1  casein kinase I isoform X7

    Conserved Domains (2) summary
    cd14126
    Location:42353
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:353399
    CK1gamma_C; Casein kinase 1 gamma C terminal
  10. XM_017009068.2XP_016864557.1  casein kinase I isoform X10

  11. XM_005271895.3XP_005271952.1  casein kinase I isoform X11

    See identical proteins and their annotated locations for XP_005271952.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329375
    CK1gamma_C; Casein kinase 1 gamma C terminal
  12. XM_005271892.3XP_005271949.1  casein kinase I isoform X5

    See identical proteins and their annotated locations for XP_005271949.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328406
    CK1gamma_C; Casein kinase 1 gamma C terminal
  13. XM_005271894.3XP_005271951.1  casein kinase I isoform X8

    See identical proteins and their annotated locations for XP_005271951.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328406
    CK1gamma_C; Casein kinase 1 gamma C terminal
  14. XM_017009070.2XP_016864559.1  casein kinase I isoform X13

    Conserved Domains (2) summary
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:328374
    CK1gamma_C; Casein kinase 1 gamma C terminal
  15. XM_017009062.1XP_016864551.1  casein kinase I isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044722.1: Suppressed sequence

    Description
    NM_001044722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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