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MDP1 magnesium dependent phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 145553, updated on 12-Oct-2019

Summary

Official Symbol
MDP1provided by HGNC
Official Full Name
magnesium dependent phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:28781
See related
Ensembl:ENSG00000213920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP-1; FN6PASE
Expression
Ubiquitous expression in adrenal (RPKM 7.9), kidney (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See MDP1 in Genome Data Viewer
Location:
14q12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24213937..24216070, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24683143..24685276, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis specific serine kinase 4 Neighboring gene charged multivesicular body protein 4A Neighboring gene Sharpr-MPRA regulatory region 5945 Neighboring gene NEDD8-MDP1 readthrough Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene Sharpr-MPRA regulatory region 3923 Neighboring gene guanosine monophosphate reductase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CHMP4A

Readthrough NEDD8-MDP1

Readthrough gene: NEDD8-MDP1, Included gene: NEDD8

Homology

Clone Names

  • MGC5987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
magnesium-dependent phosphatase 1
Names
fructosamine-6-phosphatase
NP_001186750.1
NP_001186751.1
NP_612485.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199821.1NP_001186750.1  magnesium-dependent phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_001186750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918790, BC046912, DA287183
    Consensus CDS
    CCDS55908.1
    UniProtKB/Swiss-Prot
    Q86V88
    Related
    ENSP00000380045.2, ENST00000396833.2
    Conserved Domains (1) summary
    cl21460
    Location:386
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_001199822.1NP_001186751.1  magnesium-dependent phosphatase 1 isoform 3

    See identical proteins and their annotated locations for NP_001186751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918790, CB046258, DA287183
    Conserved Domains (1) summary
    pfam12689
    Location:3135
    Acid_PPase; Acid Phosphatase
  3. NM_138476.4NP_612485.2  magnesium-dependent phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_612485.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA918790, BC051382, DA287183
    Consensus CDS
    CCDS9620.1
    UniProtKB/Swiss-Prot
    Q86V88
    Related
    ENSP00000288087.7, ENST00000288087.12
    Conserved Domains (1) summary
    pfam12689
    Location:3160
    Acid_PPase; Acid Phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24213937..24216070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    514915..517048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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