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Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) [ Mus musculus (house mouse) ]

Gene ID: 14555, updated on 1-Mar-2024

Summary

Official Symbol
Gpd1provided by MGI
Official Full Name
glycerol-3-phosphate dehydrogenase 1 (soluble)provided by MGI
Primary source
MGI:MGI:95679
See related
Ensembl:ENSMUSG00000023019 AllianceGenome:MGI:95679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gdc1; GPD-C; Gdc-1; GPDH-C
Summary
Enables glycerol-3-phosphate dehydrogenase [NAD+] activity. Acts upstream of or within several processes, including cellular response to cAMP; gluconeogenesis; and glycerophosphate shuttle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; liver; and nervous system. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 391.7), subcutaneous fat pad adult (RPKM 371.7) and 13 other tissues See more
Orthologs
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Genomic context

See Gpd1 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99615468..99622895)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99717587..99725014)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39720 Neighboring gene predicted gene, 34939 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene 16537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99555871-99556054 Neighboring gene cytochrome c oxidase assembly protein 14 Neighboring gene ceramide synthase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4010

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within NADH oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NADH oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycerol-3-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerol-3-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glycerophosphate shuttle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of glycerol-3-phosphate dehydrogenase complex TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Names
glycerolphosphate dehydrogenase 1, cytoplasmic adult
NP_034401.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010271.3NP_034401.1  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

    See identical proteins and their annotated locations for NP_034401.1

    Status: VALIDATED

    Source sequence(s)
    AK018733, AK137134
    Consensus CDS
    CCDS27828.1
    UniProtKB/Swiss-Prot
    P13707, Q3UVM3, Q5DTS5
    UniProtKB/TrEMBL
    E0CXN5
    Related
    ENSMUSP00000023760.7, ENSMUST00000023760.13
    Conserved Domains (3) summary
    TIGR03376
    Location:5342
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:5172
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:194335
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99615468..99622895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)