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FAM161B FAM161 centrosomal protein B [ Homo sapiens (human) ]

Gene ID: 145483, updated on 5-May-2024

Summary

Official Symbol
FAM161Bprovided by HGNC
Official Full Name
FAM161 centrosomal protein Bprovided by HGNC
Primary source
HGNC:HGNC:19854
See related
Ensembl:ENSG00000156050 AllianceGenome:HGNC:19854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf44; c14_5547
Summary
Predicted to be involved in cilium organization. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See FAM161B in Genome Data Viewer
Location:
14q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73922699..73950094, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68130075..68157747, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74398979..74416797, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2274 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74302771-74302949 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74305149-74305318 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74318268-74318670 Neighboring gene prostaglandin reductase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8722 Neighboring gene zinc finger protein 410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74416687-74417687 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74418757-74419055 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene coenzyme Q6, monooxygenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74459045-74459546 Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ31697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
colocalizes_with cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein FAM161B
Names
FAM161B, centrosomal protein
family with sequence similarity 161 member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152445.3NP_689658.3  protein FAM161B

    Status: VALIDATED

    Source sequence(s)
    AC005480, AI082216, AK302982, AW274700, BC053909, BI253737
    Consensus CDS
    CCDS9822.3
    UniProtKB/Swiss-Prot
    B7Z882, J3KNA2, Q96MY7
    Related
    ENSP00000286544.4, ENST00000286544.5
    Conserved Domains (2) summary
    pfam10595
    Location:167536
    UPF0564; Uncharacterized protein family UPF0564
    cl26511
    Location:456635
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    73922699..73950094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536475.3XP_011534777.2  protein FAM161B isoform X1

RNA

  1. XR_007063990.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68130075..68157747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375465.1XP_054231440.1  protein FAM161B isoform X1

RNA

  1. XR_008488826.1 RNA Sequence