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PTGR2 prostaglandin reductase 2 [ Homo sapiens (human) ]

Gene ID: 145482, updated on 1-Jun-2020

Summary

Official Symbol
PTGR2provided by HGNC
Official Full Name
prostaglandin reductase 2provided by HGNC
Primary source
HGNC:HGNC:20149
See related
Ensembl:ENSG00000140043 Ensembl:ENSG00000258653 MIM:608642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR2; ZADH1; HEL-S-298
Summary
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in heart (RPKM 10.6), thyroid (RPKM 9.3) and 24 other tissues See more
Orthologs

Genomic context

See PTGR2 in Genome Data Viewer
Location:
14q24.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73851831..73885726)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74318534..74352168)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene uncharacterized LOC100506476 Neighboring gene long intergenic non-protein coding RNA 2274 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene coenzyme Q6, monooxygenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF410

Homology

Clone Names

  • FLJ39091, FLJ99229, DKFZp686P10120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
13-prostaglandin reductase activity IEA
Inferred from Electronic Annotation
more info
 
15-oxoprostaglandin 13-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
15-oxoprostaglandin 13-oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prostaglandin reductase 2
Names
15-oxoprostaglandin 13-reductase
15-oxoprostaglandin-delta13-reductase
PRG-2
epididymis secretory protein Li 298
epididymis secretory sperm binding protein
zinc binding alcohol dehydrogenase, domain containing 1
zinc-binding alcohol dehydrogenase domain-containing protein 1
NP_001139626.1
NP_001139627.1
NP_001358254.1
NP_001358255.1
NP_001358256.1
NP_001358257.1
NP_001358258.1
NP_001358259.1
NP_001358260.1
NP_001358261.1
NP_001358263.1
NP_001358264.1
NP_689657.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146154.2NP_001139626.1  prostaglandin reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_001139626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC005520, AY346133, BP357520, BU616297
    Consensus CDS
    CCDS9820.1
    UniProtKB/Swiss-Prot
    Q8N8N7
    UniProtKB/TrEMBL
    V9HW32
    Related
    ENSP00000452280.1, ENST00000555661.5
    Conserved Domains (1) summary
    cd08293
    Location:1345
    PTGR2; Prostaglandin reductase
  2. NM_001146155.3NP_001139627.1  prostaglandin reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_001139627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC005520, BC059364, BU616297, DR158023
    Consensus CDS
    CCDS9820.1
    UniProtKB/Swiss-Prot
    Q8N8N7
    UniProtKB/TrEMBL
    V9HW32
    Related
    ENSP00000450975.1, ENST00000555228.5
    Conserved Domains (1) summary
    cd08293
    Location:1345
    PTGR2; Prostaglandin reductase
  3. NM_001371325.1NP_001358254.1  prostaglandin reductase 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC005520
  4. NM_001371326.1NP_001358255.1  prostaglandin reductase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005520
  5. NM_001371327.1NP_001358256.1  prostaglandin reductase 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005520
  6. NM_001371328.1NP_001358257.1  prostaglandin reductase 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005520
    Related
    ENSP00000451484.1, ENST00000556551.2
  7. NM_001371329.1NP_001358258.1  prostaglandin reductase 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005520
  8. NM_001371330.1NP_001358259.1  prostaglandin reductase 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005520
  9. NM_001371331.1NP_001358260.1  prostaglandin reductase 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005520
  10. NM_001371332.1NP_001358261.1  prostaglandin reductase 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005520
    Related
    ENSP00000450824.1, ENST00000553813.1
  11. NM_001371334.1NP_001358263.1  prostaglandin reductase 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC005520
  12. NM_001371335.1NP_001358264.1  prostaglandin reductase 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC005520
  13. NM_152444.4NP_689657.1  prostaglandin reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_689657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC005520, BC059364, BU616297
    Consensus CDS
    CCDS9820.1
    UniProtKB/Swiss-Prot
    Q8N8N7
    UniProtKB/TrEMBL
    V9HW32
    Related
    ENSP00000267568.4, ENST00000267568.8
    Conserved Domains (1) summary
    cd08293
    Location:1345
    PTGR2; Prostaglandin reductase

RNA

  1. NR_163921.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005520

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    73851831..73885726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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