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SLC38A6 solute carrier family 38 member 6 [ Homo sapiens (human) ]

Gene ID: 145389, updated on 15-Nov-2022

Summary

Official Symbol
SLC38A6provided by HGNC
Official Full Name
solute carrier family 38 member 6provided by HGNC
Primary source
HGNC:HGNC:19863
See related
Ensembl:ENSG00000139974 MIM:616518; AllianceGenome:HGNC:19863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAT-1; SNAT6
Summary
Predicted to enable L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.1), gall bladder (RPKM 1.9) and 24 other tissues See more
Orthologs
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Genomic context

See SLC38A6 in Genome Data Viewer
Location:
14q23.1
Exon count:
25
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60981245..61083733)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (55187785..55290408)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (61447963..61550451)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene Sharpr-MPRA regulatory region 12651 Neighboring gene RNA, U6 small nuclear 398, pseudogene Neighboring gene uncharacterized LOC101927756 Neighboring gene tRNA methyltransferase 5 Neighboring gene protein kinase C eta Neighboring gene PRKCH antisense RNA 1 Neighboring gene transmembrane protein 30B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 38, member 6 (SLC38A6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
probable sodium-coupled neutral amino acid transporter 6
Names
N system amino acid transporter NAT-1
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 6
Sodium-coupled neutral amino acid transporter 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172702.2NP_001166173.1  probable sodium-coupled neutral amino acid transporter 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest coding transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC050349, BX248072, DR002669
    Consensus CDS
    CCDS53900.1
    UniProtKB/Swiss-Prot
    Q8IZM9
    Related
    ENSP00000395851.1, ENST00000451406.5
    Conserved Domains (2) summary
    COG0814
    Location:50434
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:46429
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_153811.3NP_722518.2  probable sodium-coupled neutral amino acid transporter 6 isoform 2

    See identical proteins and their annotated locations for NP_722518.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL160234, BC110378, BX648332
    Consensus CDS
    CCDS9751.1
    UniProtKB/Swiss-Prot
    Q86SY5, Q8IZM9
    Related
    ENSP00000267488.4, ENST00000267488.9
    Conserved Domains (2) summary
    COG0814
    Location:50451
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:46451
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. NR_033344.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, and uses an alternate splice acceptor site at the terminal exon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303839, AL160236, BC050349, BP352279, BX248072, DC394244
    Related
    ENST00000529345.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    60981245..61083733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021022.2XP_016876511.1  probable sodium-coupled neutral amino acid transporter 6 isoform X4

  2. XM_047431002.1XP_047286958.1  probable sodium-coupled neutral amino acid transporter 6 isoform X1

  3. XM_017021020.2XP_016876509.1  probable sodium-coupled neutral amino acid transporter 6 isoform X1

  4. XM_047431001.1XP_047286957.1  probable sodium-coupled neutral amino acid transporter 6 isoform X1

  5. XM_017021021.2XP_016876510.1  probable sodium-coupled neutral amino acid transporter 6 isoform X2

  6. XM_047431003.1XP_047286959.1  probable sodium-coupled neutral amino acid transporter 6 isoform X2

  7. XM_017021023.2XP_016876512.1  probable sodium-coupled neutral amino acid transporter 6 isoform X5

  8. XM_047431005.1XP_047286961.1  probable sodium-coupled neutral amino acid transporter 6 isoform X6

  9. XM_047431006.1XP_047286962.1  probable sodium-coupled neutral amino acid transporter 6 isoform X7

  10. XM_047431004.1XP_047286960.1  probable sodium-coupled neutral amino acid transporter 6 isoform X3

  11. XM_047431008.1XP_047286964.1  probable sodium-coupled neutral amino acid transporter 6 isoform X11

  12. XM_047431009.1XP_047286965.1  probable sodium-coupled neutral amino acid transporter 6 isoform X12

  13. XM_047431010.1XP_047286966.1  probable sodium-coupled neutral amino acid transporter 6 isoform X13

    Related
    ENSP00000515189.1, ENST00000703134.1
  14. XM_011536469.3XP_011534771.1  probable sodium-coupled neutral amino acid transporter 6 isoform X9

    Conserved Domains (1) summary
    cl00456
    Location:46309
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  15. XM_017021025.2XP_016876514.1  probable sodium-coupled neutral amino acid transporter 6 isoform X8

  16. XM_047431007.1XP_047286963.1  probable sodium-coupled neutral amino acid transporter 6 isoform X10

  17. XM_024449496.2XP_024305264.1  probable sodium-coupled neutral amino acid transporter 6 isoform X14

    Conserved Domains (1) summary
    cl00456
    Location:3228
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_007063987.1 RNA Sequence

  2. XR_007063988.1 RNA Sequence

  3. XR_001750164.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    55187785..55290408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)