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Gcnt2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme [ Mus musculus (house mouse) ]

Gene ID: 14538, updated on 12-Aug-2019

Summary

Official Symbol
Gcnt2provided by MGI
Official Full Name
glucosaminyl (N-acetyl) transferase 2, I-branching enzymeprovided by MGI
Primary source
MGI:MGI:1100870
See related
Ensembl:ENSMUSG00000021360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGnT; IGnTA; IGnTB; IGnTC; 5330430K10Rik
Expression
Ubiquitous expression in lung adult (RPKM 3.0), placenta adult (RPKM 3.0) and 27 other tissues See more
Orthologs

Genomic context

See Gcnt2 in Genome Data Viewer
Location:
13 A3.3; 13 20.12 cM
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (40859768..40960892)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (40955501..41056261)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene oogenesin 2 pseudogene Neighboring gene predicted gene, 35160 Neighboring gene microRNA 5124a Neighboring gene predicted gene, 31683 Neighboring gene RIKEN cDNA A730081D07 gene Neighboring gene PAK1 interacting protein 1 Neighboring gene transmembrane protein 14C

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring glycosyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
maintenance of lens transparency ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
posttranscriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Names
I-branching enzyme
N-acetylglucosaminyltransferase
beta-1,6-N-acetylglucosaminyltransferase
glucosaminyltransferase, I-branching enzyme
large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase
NP_032131.2
NP_076376.3
NP_573482.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008105.3NP_032131.2  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A

    See identical proteins and their annotated locations for NP_032131.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform A.
    Source sequence(s)
    AY435149, BM933481, BY068011, CJ167392, CJ178615
    Consensus CDS
    CCDS26468.1
    UniProtKB/Swiss-Prot
    P97402
    Related
    ENSMUSP00000070942.7, ENSMUST00000069958.14
    Conserved Domains (1) summary
    pfam02485
    Location:95357
    Branch; Core-2/I-Branching enzyme
  2. NM_023887.4NP_076376.3  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B

    See identical proteins and their annotated locations for NP_076376.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' exon which includes 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (B) is of the same size but has a different N-terminus when compared to isoform A.
    Source sequence(s)
    AY435148, BC094572, BM933481
    Consensus CDS
    CCDS36637.1
    UniProtKB/TrEMBL
    Q6T5E4
    Related
    ENSMUSP00000105820.2, ENSMUST00000110191.9
    Conserved Domains (1) summary
    pfam02485
    Location:95357
    Branch; Core-2/I-Branching enzyme
  3. NM_133219.1NP_573482.1  N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform C

    See identical proteins and their annotated locations for NP_573482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon which includes 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (C) is of the same size but has a different N-terminus when compared to isoform A.
    Source sequence(s)
    BC054845, BY208177
    Consensus CDS
    CCDS26469.1
    UniProtKB/TrEMBL
    Q7TPQ8
    Related
    ENSMUSP00000066467.6, ENSMUST00000067778.7
    Conserved Domains (1) summary
    pfam02485
    Location:95357
    Branch; Core-2/I-Branching enzyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p6 C57BL/6J

    Range
    40859768..40960892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950428.1 RNA Sequence

  2. XR_003950430.1 RNA Sequence

  3. XR_003950429.1 RNA Sequence

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