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PPP1R36 protein phosphatase 1 regulatory subunit 36 [ Homo sapiens (human) ]

Gene ID: 145376, updated on 17-Jun-2024

Summary

Official Symbol
PPP1R36provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 36provided by HGNC
Primary source
HGNC:HGNC:20097
See related
Ensembl:ENSG00000165807 MIM:619923; AllianceGenome:HGNC:20097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf50
Summary
Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 17.6), stomach (RPKM 2.2) and 4 other tissues See more
Orthologs
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Genomic context

See PPP1R36 in Genome Data Viewer
Location:
14q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64549961..64589381)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58757758..58797178)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65016679..65056099)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8535 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64970928-64971598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5837 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8536 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5839 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65039864-65040400 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene nucleoporin 50 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65099836-65100338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65142104-65142604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65142605-65143105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65146682-65147226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65169421-65169922 Neighboring gene NANOG hESC enhancer GRCh37_chr14:65175156-65175657 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65181995-65182914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65182915-65183832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65184752-65185669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65194651-65195302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65195956-65196607 Neighboring gene pleckstrin homology and RhoGEF domain containing G3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65202813-65203735 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65203736-65204657 Neighboring gene spectrin beta, erythrocytic

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172365.3NP_758953.1  protein phosphatase 1 regulatory subunit 36

    See identical proteins and their annotated locations for NP_758953.1

    Status: VALIDATED

    Source sequence(s)
    AL049869, BC068989
    Consensus CDS
    CCDS9767.1
    UniProtKB/Swiss-Prot
    Q6NTH6, Q96LQ0
    Related
    ENSP00000298705.1, ENST00000298705.6
    Conserved Domains (1) summary
    pfam14895
    Location:79412
    PPPI_inhib; Protein phosphatase 1 inhibitor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64549961..64589381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430998.1XP_047286954.1  protein phosphatase 1 regulatory subunit 36 isoform X4

  2. XM_011536468.4XP_011534770.1  protein phosphatase 1 regulatory subunit 36 isoform X3

    Conserved Domains (1) summary
    pfam14895
    Location:79367
    PPPI_inhib; Protein phosphatase 1 inhibitor
  3. XM_047430999.1XP_047286955.1  protein phosphatase 1 regulatory subunit 36 isoform X4

  4. XM_005267355.5XP_005267412.1  protein phosphatase 1 regulatory subunit 36 isoform X2

    Conserved Domains (1) summary
    pfam14895
    Location:35368
    PPPI_inhib; Protein phosphatase 1 inhibitor
  5. XM_047431000.1XP_047286956.1  protein phosphatase 1 regulatory subunit 36 isoform X4

  6. XM_005267354.5XP_005267411.1  protein phosphatase 1 regulatory subunit 36 isoform X1

    Conserved Domains (1) summary
    pfam14895
    Location:67400
    PPPI_inhib; Protein phosphatase 1 inhibitor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    58757758..58797178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375437.1XP_054231412.1  protein phosphatase 1 regulatory subunit 36 isoform X4

  2. XM_054375436.1XP_054231411.1  protein phosphatase 1 regulatory subunit 36 isoform X3

  3. XM_054375438.1XP_054231413.1  protein phosphatase 1 regulatory subunit 36 isoform X4

  4. XM_054375435.1XP_054231410.1  protein phosphatase 1 regulatory subunit 36 isoform X2

  5. XM_054375439.1XP_054231414.1  protein phosphatase 1 regulatory subunit 36 isoform X4

  6. XM_054375434.1XP_054231409.1  protein phosphatase 1 regulatory subunit 36 isoform X1