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SERPINA12 serpin family A member 12 [ Homo sapiens (human) ]

Gene ID: 145264, updated on 5-Jul-2020

Summary

Official Symbol
SERPINA12provided by HGNC
Official Full Name
serpin family A member 12provided by HGNC
Primary source
HGNC:HGNC:18359
See related
Ensembl:ENSG00000165953 MIM:617471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OL-64
Expression
Restricted expression toward skin (RPKM 63.5) See more
Orthologs

Genomic context

See SERPINA12 in Genome Data Viewer
Location:
14q32.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94481651..94517844, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94953611..94984181, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370635 Neighboring gene serpin family A member 9 Neighboring gene serpin family A member 4 Neighboring gene serpin family A member 5 Neighboring gene uncharacterized LOC112268127

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serpin A12
Names
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
vaspin
visceral adipose tissue-derived serine protease inhibitor
visceral adipose-specific SERPIN

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304461.2NP_001291390.1  serpin A12 precursor

    See identical proteins and their annotated locations for NP_001291390.1

    Status: VALIDATED

    Source sequence(s)
    AL132708, AY326420
    Consensus CDS
    CCDS9926.1
    UniProtKB/Swiss-Prot
    Q8IW75
    Related
    ENSP00000451738.1, ENST00000556881.5
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  2. NM_001382267.1NP_001369196.1  serpin A12 precursor

    Status: VALIDATED

    Source sequence(s)
    AL132708
  3. NM_173850.4NP_776249.1  serpin A12 precursor

    See identical proteins and their annotated locations for NP_776249.1

    Status: VALIDATED

    Source sequence(s)
    AL132708, AL132990, BC040857
    Consensus CDS
    CCDS9926.1
    UniProtKB/Swiss-Prot
    Q8IW75
    Related
    ENSP00000342109.2, ENST00000341228.2
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94481651..94517844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536455.1XP_011534757.1  serpin A12 isoform X2

    Conserved Domains (1) summary
    cl00137
    Location:52351
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. XM_011536454.3XP_011534756.1  serpin A12 isoform X1

    See identical proteins and their annotated locations for XP_011534756.1

    UniProtKB/Swiss-Prot
    Q8IW75
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  3. XM_017020990.1XP_016876479.1  serpin A12 isoform X1

    UniProtKB/Swiss-Prot
    Q8IW75
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  4. XM_017020989.2XP_016876478.1  serpin A12 isoform X1

    UniProtKB/Swiss-Prot
    Q8IW75
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  5. XM_011536452.3XP_011534754.1  serpin A12 isoform X1

    See identical proteins and their annotated locations for XP_011534754.1

    UniProtKB/Swiss-Prot
    Q8IW75
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  6. XM_011536453.2XP_011534755.1  serpin A12 isoform X1

    See identical proteins and their annotated locations for XP_011534755.1

    UniProtKB/Swiss-Prot
    Q8IW75
    Conserved Domains (1) summary
    cd02056
    Location:52408
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
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