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Gcg glucagon [ Mus musculus (house mouse) ]

Gene ID: 14526, updated on 2-Jul-2024

Summary

Official Symbol
Gcgprovided by MGI
Official Full Name
glucagonprovided by MGI
Primary source
MGI:MGI:95674
See related
Ensembl:ENSMUSG00000000394 AllianceGenome:MGI:95674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glu; PPG; GLP-1
Summary
This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]
Expression
Biased expression in large intestine adult (RPKM 20.8), colon adult (RPKM 13.3) and 2 other tissues See more
Orthologs
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Genomic context

See Gcg in Genome Data Viewer
Location:
2 C1.3; 2 35.85 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62304874..62313997, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62474530..62483653, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62229877-62230177 Neighboring gene STARR-seq mESC enhancer starr_04638 Neighboring gene STARR-seq mESC enhancer starr_04639 Neighboring gene STARR-positive B cell enhancer ABC_E5925 Neighboring gene STARR-positive B cell enhancer ABC_E8786 Neighboring gene STARR-positive B cell enhancer ABC_E8787 Neighboring gene STARR-seq mESC enhancer starr_04641 Neighboring gene STARR-positive B cell enhancer ABC_E3379 Neighboring gene STARR-positive B cell enhancer ABC_E2037 Neighboring gene STARR-positive B cell enhancer ABC_E5926 Neighboring gene STARR-positive B cell enhancer ABC_E5927 Neighboring gene predicted gene 13561 Neighboring gene Gcg promoter region Neighboring gene fibroblast activation protein Neighboring gene STARR-seq mESC enhancer starr_04642 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene predicted gene, 39839

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gastric inhibitory polypeptide receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables glucagon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucagon receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucagon stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
pro-glucagon
Names
glucagon-like peptide I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008100.4NP_032126.1  pro-glucagon preproprotein

    See identical proteins and their annotated locations for NP_032126.1

    Status: REVIEWED

    Source sequence(s)
    AK148544, AL928576
    Consensus CDS
    CCDS16066.1
    UniProtKB/Swiss-Prot
    P55095, Q3UFE9
    UniProtKB/TrEMBL
    A2AS86
    Related
    ENSMUSP00000099794.4, ENSMUST00000102733.10
    Conserved Domains (2) summary
    smart00070
    Location:5379
    GLUCA; Glucagon like hormones
    pfam00123
    Location:98124
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    62304874..62313997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)