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CSNK1A1 casein kinase 1 alpha 1 [ Homo sapiens (human) ]

Gene ID: 1452, updated on 17-Jun-2019

Summary

Official Symbol
CSNK1A1provided by HGNC
Official Full Name
casein kinase 1 alpha 1provided by HGNC
Primary source
HGNC:HGNC:2451
See related
Ensembl:ENSG00000113712 MIM:600505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
Expression
Ubiquitous expression in esophagus (RPKM 69.2), gall bladder (RPKM 47.2) and 25 other tissues See more
Orthologs

Genomic context

See CSNK1A1 in Genome Data Viewer
Location:
5q32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (149492982..149551439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148873896..148931115, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143 Neighboring gene microRNA 145 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene Sharpr-MPRA regulatory region 10925 Neighboring gene RNA, U6 small nuclear 588, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex assembly TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium TAS
Traceable Author Statement
more info
 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
casein kinase I isoform alpha
Names
CKI-alpha
clock regulator kinase
down-regulated in lung cancer
epididymis secretory sperm binding protein Li 77p
NP_001020276.1
NP_001258670.1
NP_001258671.1
NP_001883.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025105.3NP_001020276.1  casein kinase I isoform alpha isoform 1

    See identical proteins and their annotated locations for NP_001020276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021078, BC008717, BC021971, BU618830, DA144898, DQ082865
    Consensus CDS
    CCDS47304.1
    UniProtKB/Swiss-Prot
    P48729
    UniProtKB/TrEMBL
    Q6PJ06
    Related
    ENSP00000421689.1, ENST00000515768.5
    Conserved Domains (1) summary
    cd14128
    Location:16309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  2. NM_001271741.2NP_001258670.1  casein kinase I isoform alpha isoform 3

    See identical proteins and their annotated locations for NP_001258670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame internal exon and uses an alternate splice site, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC021078, AF218004, BC008717, BC009186, BU618830, DA144898
    Consensus CDS
    CCDS64291.1
    UniProtKB/Swiss-Prot
    P48729
    Related
    ENSP00000261798.5, ENST00000261798.9
    Conserved Domains (1) summary
    cd14128
    Location:16281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
  3. NM_001271742.2NP_001258671.1  casein kinase I isoform alpha isoform 4

    See identical proteins and their annotated locations for NP_001258671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021078, AK293761, BC008717, BU618830, HY119498
    UniProtKB/Swiss-Prot
    P48729
    UniProtKB/TrEMBL
    B4DER9
    Related
    ENSP00000427031.1, ENST00000515435.5
    Conserved Domains (1) summary
    cl21453
    Location:1220
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001892.6NP_001883.4  casein kinase I isoform alpha isoform 2

    See identical proteins and their annotated locations for NP_001883.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame internal exon, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC021078, BC008717, BC009186, BU618830, DA144898, L37042
    Consensus CDS
    CCDS47303.1
    UniProtKB/Swiss-Prot
    P48729
    Related
    ENSP00000367074.2, ENST00000377843.6
    Conserved Domains (1) summary
    cd14128
    Location:16281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    149492982..149551439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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