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gnsA putative phosphatidylethanolamine synthesis regulator GnsA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 1450249, updated on 26-Nov-2024

Summary

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Official Symbol
gnsA
Official Full Name
putative phosphatidylethanolamine synthesis regulator GnsA
Primary source
ECOCYC:G0-9662
Locus tag
b4517
See related
ASAP:ABE-0285038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0982; sfa; yccL
Summary
[More information is available at EcoGene: EG13233]. GnsA was isolated as a multicopy suppressor of a cold-sensitive secG mutant . [More information is available at EcoCyc: G0-9662].
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Genomic context

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Sequence:
NC_000913.3 (1052067..1052240)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cold shock protein CspG Neighboring gene protein YmcF Neighboring gene protein YmcE Neighboring gene putative electron transport protein YccM Neighboring gene sensor histidine kinase TorS

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of GnsA from Escherichia coli. Wei Y, et al. Biochem Biophys Res Commun, 2015 Jun 19. PMID 25839658
  2. Overexpression of gnsA, a multicopy suppressor of the secG null mutation, increases acidic phospholipid contents by inhibiting phosphatidylethanolamine synthesis at low temperatures. Sugai R, et al. J Bacteriol, 2004 Sep. PMID 15317805, Free PMC Article
  3. Increased unsaturated fatty acid production associated with a suppressor of the fabA6(Ts) mutation in Escherichia coli. Rock CO, et al. J Bacteriol, 1996 Sep. PMID 8808925, Free PMC Article
  4. Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli. Sugai R, et al. J Bacteriol, 2001 Oct. PMID 11544213, Free PMC Article
  5. Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Liu F, et al. Nat Commun, 2017 May 19. PMID 28524877, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative phosphatidylethanolamine synthesis regulator GnsA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1052067..1052240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_588446.1 putative phosphatidylethanolamine synthesis regulator GnsA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_588446.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L9II02
    Conserved Domains (1) summary
    pfam08178
    Location:1 → 54
    GnsAB_toxin; GnsA/GnsB toxin of bacterial toxin-antitoxin system
Nucleotide Protein
Heading Accession and Version

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