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RAD9B RAD9 checkpoint clamp component B [ Homo sapiens (human) ]

Gene ID: 144715, updated on 26-Oct-2022

Summary

Official Symbol
RAD9Bprovided by HGNC
Official Full Name
RAD9 checkpoint clamp component Bprovided by HGNC
Primary source
HGNC:HGNC:21700
See related
Ensembl:ENSG00000151164 MIM:608368; AllianceGenome:HGNC:21700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.5), bone marrow (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See RAD9B in Genome Data Viewer
Location:
12q24.11
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (110502331..110533556)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (110480028..110511250)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110940136..110971361)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903016 Neighboring gene family with sequence similarity 216 member A Neighboring gene uncharacterized LOC124903015 Neighboring gene small nucleolar RNA SNORD50 Neighboring gene VPS29 retromer complex component Neighboring gene protein phosphatase targeting COQ7 Neighboring gene HNF4 motif-containing MPRA enhancer 250 Neighboring gene tectonic family member 1 Neighboring gene RNA, 7SL, cytoplasmic 387, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40346, MGC75426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell cycle checkpoint control protein RAD9B
Names
DNA repair exonuclease rad9 homolog B
RAD9 homolog B
NP_001273460.1
NP_001273461.1
NP_001273462.1
NP_001273463.1
NP_001273464.1
NP_001273465.1
NP_001354980.1
NP_001354981.1
NP_001354982.1
NP_001354983.1
NP_001354984.1
NP_001354985.1
NP_689655.3
XP_005253906.1
XP_011536274.1
XP_024304628.1
XP_047284349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286531.2NP_001273460.1  cell cycle checkpoint control protein RAD9B isoform b

    See identical proteins and their annotated locations for NP_001273460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and differs in the exon structure in the 3' coding region, compared to variant 1. It initiates translation from a downstream in-frame start codon. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 2, 3, and 8 all encode the same isoform (b).
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73527.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBN9
    Related
    ENSP00000387329.1, ENST00000409246.5
    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  2. NM_001286532.2NP_001273461.1  cell cycle checkpoint control protein RAD9B isoform b

    See identical proteins and their annotated locations for NP_001273461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' coding region and differs in the exon structure in the 3' coding region, compared to variant 1. It initiates translation from a downstream in-frame start codon. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 2, 3, and 8 all encode the same isoform (b).
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73527.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBN9
    Related
    ENSP00000386629.1, ENST00000409425.5
    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  3. NM_001286533.2NP_001273462.1  cell cycle checkpoint control protein RAD9B isoform c

    See identical proteins and their annotated locations for NP_001273462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in both the 5' and 3' coding regions, compared to variant 1, including initiation of translation from a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC002350
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBJ5
    Conserved Domains (1) summary
    pfam04139
    Location:1118
    Rad9; Rad9
  4. NM_001286534.2NP_001273463.1  cell cycle checkpoint control protein RAD9B isoform c

    See identical proteins and their annotated locations for NP_001273463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in both the 5' and 3' coding regions, compared to variant 1, including initiation of translation from a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC002350
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBJ5
    Conserved Domains (1) summary
    pfam04139
    Location:1118
    Rad9; Rad9
  5. NM_001286535.2NP_001273464.1  cell cycle checkpoint control protein RAD9B isoform d

    See identical proteins and their annotated locations for NP_001273464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the exon structure in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73526.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    B4DX60
    Related
    ENSP00000386434.1, ENST00000409300.6
    Conserved Domains (2) summary
    cd00577
    Location:9278
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:17276
    Rad9; Rad9
  6. NM_001286536.2NP_001273465.1  cell cycle checkpoint control protein RAD9B isoform e

    See identical proteins and their annotated locations for NP_001273465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons, which results in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS66469.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    B4DYM6
    Related
    ENSP00000386697.3, ENST00000409778.7
    Conserved Domains (2) summary
    pfam04139
    Location:17207
    Rad9; Rad9
    cl24017
    Location:9209
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
  7. NM_001368051.1NP_001354980.1  cell cycle checkpoint control protein RAD9B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73527.1
    UniProtKB/TrEMBL
    A0A024RBN9
  8. NM_001368052.1NP_001354981.1  cell cycle checkpoint control protein RAD9B isoform f

    Status: VALIDATED

    Source sequence(s)
    AC002350
  9. NM_001368053.1NP_001354982.1  cell cycle checkpoint control protein RAD9B isoform g

    Status: VALIDATED

    Source sequence(s)
    AC002350
  10. NM_001368054.1NP_001354983.1  cell cycle checkpoint control protein RAD9B isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform h.
    Source sequence(s)
    AC002350
  11. NM_001368055.1NP_001354984.1  cell cycle checkpoint control protein RAD9B isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform h.
    Source sequence(s)
    AC002350
  12. NM_001368056.1NP_001354985.1  cell cycle checkpoint control protein RAD9B isoform i

    Status: VALIDATED

    Source sequence(s)
    AC002350
  13. NM_152442.4NP_689655.3  cell cycle checkpoint control protein RAD9B isoform a

    See identical proteins and their annotated locations for NP_689655.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS9148.2
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    J3KPN7
    Related
    ENSP00000376440.4, ENST00000392672.8
    Conserved Domains (2) summary
    cd00577
    Location:9278
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:17276
    Rad9; Rad9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    110502331..110533556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448860.2XP_024304628.1  cell cycle checkpoint control protein RAD9B isoform X3

    UniProtKB/TrEMBL
    A0A024RBN9
    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  2. XM_005253849.6XP_005253906.1  cell cycle checkpoint control protein RAD9B isoform X2

    Conserved Domains (2) summary
    pfam04139
    Location:17207
    Rad9; Rad9
    cl24017
    Location:9209
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
  3. XM_011537972.4XP_011536274.1  cell cycle checkpoint control protein RAD9B isoform X1

    Conserved Domains (2) summary
    cd00577
    Location:9254
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:17252
    Rad9; Rad9
  4. XM_047428393.1XP_047284349.1  cell cycle checkpoint control protein RAD9B isoform X3

    UniProtKB/TrEMBL
    A0A024RBN9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    110480028..110511250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)