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RAD9B RAD9 checkpoint clamp component B [ Homo sapiens (human) ]

Gene ID: 144715, updated on 18-Aug-2020

Summary

Official Symbol
RAD9Bprovided by HGNC
Official Full Name
RAD9 checkpoint clamp component Bprovided by HGNC
Primary source
HGNC:HGNC:21700
See related
Ensembl:ENSG00000151164 MIM:608368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 7.5), bone marrow (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See RAD9B in Genome Data Viewer
Location:
12q24.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (110501651..110534632)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110940005..110973952)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 49 Neighboring gene GPN-loop GTPase 3 Neighboring gene family with sequence similarity 216 member A Neighboring gene VPS29 retromer complex component Neighboring gene protein phosphatase targeting COQ7 Neighboring gene HNF4 motif-containing MPRA enhancer 250 Neighboring gene tectonic family member 1 Neighboring gene RNA, 7SL, cytoplasmic 387, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40346, MGC75426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell cycle checkpoint control protein RAD9B
Names
DNA repair exonuclease rad9 homolog B
RAD9 homolog B
NP_001273460.1
NP_001273461.1
NP_001273462.1
NP_001273463.1
NP_001273464.1
NP_001273465.1
NP_001354980.1
NP_001354981.1
NP_001354982.1
NP_001354983.1
NP_001354984.1
NP_001354985.1
NP_689655.3
XP_005253906.1
XP_011536274.1
XP_016874366.1
XP_016874368.1
XP_016874369.1
XP_016874370.1
XP_016874371.1
XP_024304628.1
XP_024304629.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286531.2NP_001273460.1  cell cycle checkpoint control protein RAD9B isoform b

    See identical proteins and their annotated locations for NP_001273460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and differs in the exon structure in the 3' coding region, compared to variant 1. It initiates translation from a downstream in-frame start codon. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 2, 3, and 8 all encode the same isoform (b).
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73527.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBN9
    Related
    ENSP00000387329.1, ENST00000409246.5
    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  2. NM_001286532.2NP_001273461.1  cell cycle checkpoint control protein RAD9B isoform b

    See identical proteins and their annotated locations for NP_001273461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' coding region and differs in the exon structure in the 3' coding region, compared to variant 1. It initiates translation from a downstream in-frame start codon. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 2, 3, and 8 all encode the same isoform (b).
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73527.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBN9
    Related
    ENSP00000386629.1, ENST00000409425.5
    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  3. NM_001286533.2NP_001273462.1  cell cycle checkpoint control protein RAD9B isoform c

    See identical proteins and their annotated locations for NP_001273462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in both the 5' and 3' coding regions, compared to variant 1, including initiation of translation from a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC002350
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBJ5
    Conserved Domains (1) summary
    pfam04139
    Location:1118
    Rad9; Rad9
  4. NM_001286534.2NP_001273463.1  cell cycle checkpoint control protein RAD9B isoform c

    See identical proteins and their annotated locations for NP_001273463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in both the 5' and 3' coding regions, compared to variant 1, including initiation of translation from a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC002350
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBJ5
    Conserved Domains (1) summary
    pfam04139
    Location:1118
    Rad9; Rad9
  5. NM_001286535.2NP_001273464.1  cell cycle checkpoint control protein RAD9B isoform d

    See identical proteins and their annotated locations for NP_001273464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the exon structure in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS73526.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    B4DX60
    Related
    ENSP00000386434.1, ENST00000409300.5
    Conserved Domains (2) summary
    cd00577
    Location:9278
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:17276
    Rad9; Rad9
  6. NM_001286536.2NP_001273465.1  cell cycle checkpoint control protein RAD9B isoform e

    See identical proteins and their annotated locations for NP_001273465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons, which results in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS66469.1
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    B4DYM6
    Related
    ENSP00000386697.3, ENST00000409778.7
    Conserved Domains (2) summary
    pfam04139
    Location:17207
    Rad9; Rad9
    cl24017
    Location:9209
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
  7. NM_001368051.1NP_001354980.1  cell cycle checkpoint control protein RAD9B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC002350
  8. NM_001368052.1NP_001354981.1  cell cycle checkpoint control protein RAD9B isoform f

    Status: VALIDATED

    Source sequence(s)
    AC002350
  9. NM_001368053.1NP_001354982.1  cell cycle checkpoint control protein RAD9B isoform g

    Status: VALIDATED

    Source sequence(s)
    AC002350
  10. NM_001368054.1NP_001354983.1  cell cycle checkpoint control protein RAD9B isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform h.
    Source sequence(s)
    AC002350
  11. NM_001368055.1NP_001354984.1  cell cycle checkpoint control protein RAD9B isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform h.
    Source sequence(s)
    AC002350
  12. NM_001368056.1NP_001354985.1  cell cycle checkpoint control protein RAD9B isoform i

    Status: VALIDATED

    Source sequence(s)
    AC002350
  13. NM_152442.4NP_689655.3  cell cycle checkpoint control protein RAD9B isoform a

    See identical proteins and their annotated locations for NP_689655.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC002350
    Consensus CDS
    CCDS9148.2
    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    J3KPN7
    Related
    ENSP00000376440.4, ENST00000392672.8
    Conserved Domains (2) summary
    cd00577
    Location:9278
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:17276
    Rad9; Rad9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    110501651..110534632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448861.1XP_024304629.1  cell cycle checkpoint control protein RAD9B isoform X5

    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  2. XM_017018880.2XP_016874369.1  cell cycle checkpoint control protein RAD9B isoform X6

    Conserved Domains (1) summary
    cl24017
    Location:281
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
  3. XM_017018881.2XP_016874370.1  cell cycle checkpoint control protein RAD9B isoform X7

  4. XM_017018879.2XP_016874368.1  cell cycle checkpoint control protein RAD9B isoform X6

    Conserved Domains (1) summary
    cl24017
    Location:281
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
  5. XM_011537972.3XP_011536274.1  cell cycle checkpoint control protein RAD9B isoform X2

    Conserved Domains (2) summary
    cd00577
    Location:9254
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:17252
    Rad9; Rad9
  6. XM_017018877.2XP_016874366.1  cell cycle checkpoint control protein RAD9B isoform X3

  7. XM_024448860.1XP_024304628.1  cell cycle checkpoint control protein RAD9B isoform X5

    Conserved Domains (1) summary
    pfam04139
    Location:5204
    Rad9; Rad9
  8. XM_017018882.2XP_016874371.1  cell cycle checkpoint control protein RAD9B isoform X8

    UniProtKB/Swiss-Prot
    Q6WBX8
    UniProtKB/TrEMBL
    A0A024RBJ5
    Conserved Domains (1) summary
    pfam04139
    Location:1118
    Rad9; Rad9
  9. XM_005253849.5XP_005253906.1  cell cycle checkpoint control protein RAD9B isoform X4

    Conserved Domains (2) summary
    pfam04139
    Location:17207
    Rad9; Rad9
    cl24017
    Location:9209
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
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