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FBXL14 F-box and leucine rich repeat protein 14 [ Homo sapiens (human) ]

Gene ID: 144699, updated on 21-Dec-2019

Summary

Official Symbol
FBXL14provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 14provided by HGNC
Primary source
HGNC:HGNC:28624
See related
Ensembl:ENSG00000171823 MIM:609081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbl14
Summary
Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 7.1), colon (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See FBXL14 in Genome Data Viewer
Location:
12p13.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (1559641..1594581, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1675159..1703331, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 942 Neighboring gene uncharacterized LOC107984507 Neighboring gene Wnt family member 5B Neighboring gene microRNA 3649 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene adiponectin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/LRR-repeat protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152441.3NP_689654.1  F-box/LRR-repeat protein 14

    See identical proteins and their annotated locations for NP_689654.1

    Status: VALIDATED

    Source sequence(s)
    AC004671, AC005182
    Consensus CDS
    CCDS8509.1
    UniProtKB/Swiss-Prot
    Q8N1E6
    Related
    ENSP00000344855.3, ENST00000339235.4
    Conserved Domains (3) summary
    sd00034
    Location:145170
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:546
    F-box-like; F-box-like
    cl28166
    Location:228401
    AMN1; Antagonist of mitotic exit network protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    1559641..1594581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018875.2XP_016874364.1  F-box/LRR-repeat protein 14 isoform X1

    Conserved Domains (3) summary
    sd00034
    Location:145170
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:546
    F-box-like; F-box-like
    cl28166
    Location:90296
    AMN1; Antagonist of mitotic exit network protein 1
  2. XM_017018876.2XP_016874365.1  F-box/LRR-repeat protein 14 isoform X2

    Conserved Domains (3) summary
    sd00034
    Location:145170
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:546
    F-box-like; F-box-like
    cl28166
    Location:90296
    AMN1; Antagonist of mitotic exit network protein 1

RNA

  1. XR_001748600.2 RNA Sequence

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