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Gbp2b guanylate binding protein 2b [ Mus musculus (house mouse) ]

Gene ID: 14468, updated on 8-Feb-2024

Summary

Official Symbol
Gbp2bprovided by MGI
Official Full Name
guanylate binding protein 2bprovided by MGI
Primary source
MGI:MGI:95666
See related
Ensembl:ENSMUSG00000040264 AllianceGenome:MGI:95666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbp1; Mpa1; Gbp-1; LIMIT; Mag-1; Mpa-1
Summary
Enables GMP binding activity. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Orthologous to human GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 1.6), bladder adult (RPKM 0.7) and 12 other tissues See more
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Genomic context

See Gbp2b in Genome Data Viewer
Location:
3 H1; 3 66.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142300577..142324940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142594816..142619179)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E3478 Neighboring gene guanylate binding protein 3 Neighboring gene predicted gene, 40158 Neighboring gene STARR-positive B cell enhancer ABC_E10218 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142263123-142263423 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142282846-142283147 Neighboring gene predicted gene, 54185 Neighboring gene microRNA 6381 Neighboring gene guanylate binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_09157 Neighboring gene STARR-seq mESC enhancer starr_09159 Neighboring gene guanylate binding protein 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC124334, 5830475C06

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity ISO
Inferred from Sequence Orthology
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables GMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adhesion of symbiont to host IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytolysis in another organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in symbiont cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanylate-binding protein 1
Names
GTP-binding protein 1
guanylate nucleotide binding protein 1
interferon-gamma-inducible protein MAG-1
interferon-induced guanylate-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010259.2NP_034389.2  guanylate-binding protein 1

    See identical proteins and their annotated locations for NP_034389.2

    Status: VALIDATED

    Source sequence(s)
    AC102108, AK077796
    Consensus CDS
    CCDS38658.1
    UniProtKB/Swiss-Prot
    Q01514, Q32MT4
    UniProtKB/TrEMBL
    A4UUI2
    Related
    ENSMUSP00000029936.5, ENSMUST00000029936.5
    Conserved Domains (2) summary
    pfam02263
    Location:19280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282578
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142300577..142324940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240014.1XP_011238316.1  guanylate-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q01514, Q32MT4
    Conserved Domains (2) summary
    pfam02263
    Location:19280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282553
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_030252421.2XP_030108281.1  guanylate-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q01514, Q32MT4
    UniProtKB/TrEMBL
    A4UUI2
    Conserved Domains (2) summary
    pfam02263
    Location:19280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282578
    GBP_C; Guanylate-binding protein, C-terminal domain