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C12orf60 chromosome 12 open reading frame 60 [ Homo sapiens (human) ]

Gene ID: 144608, updated on 23-Nov-2021

Summary

Official Symbol
C12orf60provided by HGNC
Official Full Name
chromosome 12 open reading frame 60provided by HGNC
Primary source
HGNC:HGNC:28726
See related
Ensembl:ENSG00000182993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 3.6), duodenum (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See C12orf60 in Genome Data Viewer
Location:
12p13.1-p12.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (14567991..14824415)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14956604..14977349)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928317 Neighboring gene phospholipase B domain containing 1 Neighboring gene RN7SK pseudogene 134 Neighboring gene PLBD1 antisense RNA 1 Neighboring gene guanylate cyclase 2C Neighboring gene uncharacterized LOC105369669 Neighboring gene H4 histone 16 Neighboring gene H2A.J histone Neighboring gene WW domain binding protein 11 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) Neighboring gene matrix Gla protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31651, MGC47869

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
uncharacterized protein C12orf60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175874.4NP_787070.2  uncharacterized protein C12orf60

    See identical proteins and their annotated locations for NP_787070.2

    Status: VALIDATED

    Source sequence(s)
    AC007655, BC015546, BC038836
    Consensus CDS
    CCDS8667.1
    UniProtKB/Swiss-Prot
    Q5U649
    Related
    ENSP00000331691.2, ENST00000330828.3
    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    14567991..14824415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448858.1XP_024304626.1  uncharacterized protein C12orf60 isoform X1

    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)
  2. XM_024448859.1XP_024304627.1  uncharacterized protein C12orf60 isoform X1

    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)
  3. XM_017018873.1XP_016874362.1  uncharacterized protein C12orf60 isoform X1

    UniProtKB/Swiss-Prot
    Q5U649
    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)
  4. XM_017018874.1XP_016874363.1  uncharacterized protein C12orf60 isoform X1

    UniProtKB/Swiss-Prot
    Q5U649
    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)
  5. XM_005253322.4XP_005253379.1  uncharacterized protein C12orf60 isoform X1

    See identical proteins and their annotated locations for XP_005253379.1

    UniProtKB/Swiss-Prot
    Q5U649
    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)
  6. XM_011520569.2XP_011518871.1  uncharacterized protein C12orf60 isoform X1

    See identical proteins and their annotated locations for XP_011518871.1

    UniProtKB/Swiss-Prot
    Q5U649
    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)
  7. XM_011520568.2XP_011518870.1  uncharacterized protein C12orf60 isoform X1

    See identical proteins and their annotated locations for XP_011518870.1

    UniProtKB/Swiss-Prot
    Q5U649
    Conserved Domains (1) summary
    pfam15047
    Location:9233
    DUF4533; Protein of unknown function (DUF4533)

RNA

  1. XR_001748595.1 RNA Sequence

  2. XR_001748597.1 RNA Sequence

  3. XR_001748596.1 RNA Sequence

  4. XR_001748598.2 RNA Sequence

  5. XR_001748599.1 RNA Sequence

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