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Gast gastrin [ Mus musculus (house mouse) ]

Gene ID: 14459, updated on 17-Jun-2024

Summary

Official Symbol
Gastprovided by MGI
Official Full Name
gastrinprovided by MGI
Primary source
MGI:MGI:104768
See related
Ensembl:ENSMUSG00000017165 AllianceGenome:MGI:104768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAS
Summary
This gene encodes the peptide hormone gastrin, which stimulates gastric acid secretion, proliferation, cell migration and angiogenesis, as well as inhibits apoptosis. The encoded preproprotein undergoes proteolytic processing to generate multiple gastrin peptides differing in size. Mice lacking the encoded protein exhibit a decrease in the number of parietal cells, achlorohydria and a decrease in the colonic proliferation. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward stomach adult (RPKM 365.6) See more
Orthologs
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Genomic context

See Gast in Genome Data Viewer
Location:
11 D; 11 63.46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100225233..100227823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100334407..100336997)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30718 Neighboring gene predicted gene 14206 Neighboring gene STARR-seq mESC enhancer starr_30725 Neighboring gene STARR-positive B cell enhancer ABC_E1148 Neighboring gene STARR-positive B cell enhancer ABC_E3019 Neighboring gene STARR-positive B cell enhancer ABC_E11493 Neighboring gene eukaryotic translation initiation factor 1 Neighboring gene huntingtin-associated protein 1 Neighboring gene predicted pseudogene 10039

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to food IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010257.4NP_034387.3  gastrin preproprotein

    See identical proteins and their annotated locations for NP_034387.3

    Status: REVIEWED

    Source sequence(s)
    AK008494, AL590968
    Consensus CDS
    CCDS25418.1
    UniProtKB/Swiss-Prot
    P48757, P70334, Q64295, Q9CPR2
    UniProtKB/TrEMBL
    Q6GSF5
    Related
    ENSMUSP00000017309.2, ENSMUST00000017309.2
    Conserved Domains (1) summary
    pfam00918
    Location:8799
    Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100225233..100227823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)