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Gas6 growth arrest specific 6 [ Mus musculus (house mouse) ]

Gene ID: 14456, updated on 1-Oct-2024

Summary

Official Symbol
Gas6provided by MGI
Official Full Name
growth arrest specific 6provided by MGI
Primary source
MGI:MGI:95660
See related
Ensembl:ENSMUSG00000031451 AllianceGenome:MGI:95660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gas-6
Summary
Enables receptor ligand activity. Acts upstream of or within several processes, including blood coagulation; neuron migration; and protein kinase B signaling. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and limb. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 548.6), adrenal adult (RPKM 311.4) and 15 other tissues See more
Orthologs
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Genomic context

See Gas6 in Genome Data Viewer
Location:
8 A1.1; 8 6.06 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13515374..13544535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13465374..13494535, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene transmembrane protein 255B Neighboring gene predicted gene, 53399 Neighboring gene RIKEN cDNA 1700029H14 gene Neighboring gene STARR-seq mESC enhancer starr_20769 Neighboring gene RAS p21 protein activator 3 Neighboring gene predicted gene, 34795

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in B cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of protein kinase B activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-alpha ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vitamin K ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vitamin K ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fusion of virus membrane with host plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in fusion of virus membrane with host plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hematopoietic stem cell migration to bone marrow ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic stem cell migration to bone marrow ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of biomineral tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of dendritic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of oligodendrocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of renal albumin absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dendritic cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated virion attachment to host cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in symbiont entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in symbiont entry into host cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
growth arrest-specific protein 6
Names
AXL receptor tyrosine kinase ligand

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019521.2NP_062394.2  growth arrest-specific protein 6 precursor

    See identical proteins and their annotated locations for NP_062394.2

    Status: VALIDATED

    Source sequence(s)
    AI482478, AK086187, CJ062651, X59846
    Consensus CDS
    CCDS40232.1
    UniProtKB/Swiss-Prot
    Q61592, Q99K57
    Related
    ENSMUSP00000033828.6, ENSMUST00000033828.7
    Conserved Domains (7) summary
    smart00069
    Location:2690
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00179
    Location:194225
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:115150
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:295447
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:510647
    Laminin_G_2; Laminin G domain
    pfam12662
    Location:215238
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:157192
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13515374..13544535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)