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CSK C-terminal Src kinase [ Homo sapiens (human) ]

Gene ID: 1445, updated on 1-Jun-2020

Summary

Official Symbol
CSKprovided by HGNC
Official Full Name
C-terminal Src kinaseprovided by HGNC
Primary source
HGNC:HGNC:2444
See related
Ensembl:ENSG00000103653 MIM:124095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Expression
Broad expression in lymph node (RPKM 63.0), spleen (RPKM 47.7) and 24 other tissues See more
Orthologs

Genomic context

See CSK in Genome Data Viewer
Location:
15q24.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74782080..74803198)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75074425..75095539)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CYP1A2 5' regulatory region Neighboring gene cytochrome P450 family 1 subfamily A member 2 Neighboring gene enhancer downstream of CYP1A2 Neighboring gene microRNA 4513 Neighboring gene lectin, mannose binding 1 like Neighboring gene uncharacterized LOC105370897 Neighboring gene complexin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
NHGRI GWA Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
Genome-wide association study of blood pressure and hypertension.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface activates Src kinases, leading to an increase in membrane extensions at the DC surface PubMed
Tat tat HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
proline-rich region binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of low-density lipoprotein particle clearance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein kinase CSK
Names
C-Src kinase
CSK, non-receptor tyrosine kinase
c-src tyrosine kinase
protein-tyrosine kinase CYL
NP_001120662.1
NP_001341917.1
NP_004374.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127190.2NP_001120662.1  tyrosine-protein kinase CSK

    See identical proteins and their annotated locations for NP_001120662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC091230, AK290531, AW575209, AY007162
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240
    UniProtKB/TrEMBL
    A8K3B6, B2R6Q4
    Related
    ENSP00000414764.2, ENST00000439220.6
    Conserved Domains (3) summary
    cd05082
    Location:188443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:1167
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
  2. NM_001354988.2NP_001341917.1  tyrosine-protein kinase CSK

    Status: REVIEWED

    Source sequence(s)
    AK127672, AW575209
    Consensus CDS
    CCDS10269.1
    Related
    ENSP00000454906.1, ENST00000567571.5
    Conserved Domains (3) summary
    cd05082
    Location:188443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:1167
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
  3. NM_004383.2NP_004374.1  tyrosine-protein kinase CSK

    See identical proteins and their annotated locations for NP_004374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW575209, BC106073
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240
    UniProtKB/TrEMBL
    B2R6Q4
    Related
    ENSP00000220003.9, ENST00000220003.13
    Conserved Domains (3) summary
    cd05082
    Location:188443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:1167
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74782080..74803198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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