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E2F7 E2F transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 144455, updated on 3-May-2025
Official Symbol
E2F7provided by HGNC
Official Full Name
E2F transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:23820
See related
Ensembl:ENSG00000165891 MIM:612046; AllianceGenome:HGNC:23820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables DNA-binding transcription repressor activity; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; and sprouting angiogenesis. Located in nuclear speck. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in testis (RPKM 1.6), bone marrow (RPKM 1.5) and 16 other tissues See more
Orthologs
mouse all
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See E2F7 in Genome Data Viewer
Location:
12q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (77021251..77065569, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (76999082..77043421, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77415031..77459349, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4675 Neighboring gene cysteine and glycine rich protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77313616-77314124 Neighboring gene Sharpr-MPRA regulatory region 9474 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:77329846-77331045 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77358407-77359020 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:77425832-77427031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4676 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:77459297-77460003 Neighboring gene Sharpr-MPRA regulatory region 14502 Neighboring gene uncharacterized LOC105369853 Neighboring gene small nucleolar RNA U13

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7. Gugnoni M, et al. Cell Death Dis, 2023 Feb 10. PMID 36765037, Free PMC Article
  2. An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Mitxelena J, et al. Nucleic Acids Res, 2018 May 18. PMID 29590434, Free PMC Article
  3. E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation. Endo-Munoz L, et al. Cancer Res, 2009 Mar 1. PMID 19223542
  4. Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis. Coutts AS, et al. Cell Death Dis, 2018 May 1. PMID 29760477, Free PMC Article
  5. E2F7 promotes mammalian target of rapamycin inhibitor resistance in hepatocellular carcinoma after liver transplantation. Ling S, et al. Am J Transplant, 2022 Oct. PMID 35729702

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer.
    Title: The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer.
  2. Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription.
    Title: Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription.
  3. p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme.
    Title: p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme.
  4. E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.
    Title: E2F7 serves as a potential prognostic biomarker for lung adenocarcinoma.
  5. CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer.
    Title: CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer.
  6. Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p.
    Title: Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p.
  7. E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
    Title: E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.
  8. VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.
    Title: VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.
  9. lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis.
    Title: lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis.
  10. Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.
    Title: Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chorionic trophoblast cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chorionic trophoblast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
  
involved_in placenta development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA endoreduplication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA endoreduplication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trophoblast giant cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription factor E2F7
Names
E2F-7

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203394.3 → NP_976328.2  transcription factor E2F7

    See identical proteins and their annotated locations for NP_976328.2

    Status: VALIDATED

    Source sequence(s)
    AC025161, AI380315, AK097677, BC017481, DB159890
    Consensus CDS
    CCDS9016.1
    UniProtKB/Swiss-Prot
    A6NC74, B2RMR7, B3KTZ5, B3KUP8, B5MED9, Q96AV8
    Related
    ENSP00000323246.7, ENST00000322886.12
    Conserved Domains (1) summary
    pfam02319
    Location:144 → 211
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    77021251..77065569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537966.3 → XP_011536268.1  transcription factor E2F7 isoform X1

    Conserved Domains (1) summary
    pfam02319
    Location:144 → 211
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. XM_011537969.3 → XP_011536271.1  transcription factor E2F7 isoform X2

    Conserved Domains (1) summary
    pfam02319
    Location:43 → 110
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    76999082..77043421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371191.1 → XP_054227166.1  transcription factor E2F7 isoform X1

  2. XM_054371192.1 → XP_054227167.1  transcription factor E2F7 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AV8.3 GenPept UniProtKB/Swiss-Prot:Q96AV8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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