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E2F7 E2F transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 144455, updated on 9-Aug-2021

Summary

Official Symbol
E2F7provided by HGNC
Official Full Name
E2F transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:23820
See related
Ensembl:ENSG00000165891 MIM:612046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]
Expression
Broad expression in testis (RPKM 1.6), bone marrow (RPKM 1.5) and 16 other tissues See more
Orthologs
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Genomic context

See E2F7 in Genome Data Viewer
Location:
12q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (77021251..77065580, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77415031..77459349, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cysteine and glycine rich protein 2 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene uncharacterized LOC105369853 Neighboring gene long intergenic non-protein coding RNA 2464

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12981

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chorionic trophoblast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepatocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription involved in G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in placenta development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA endoreduplication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transcription factor E2F7
Names
E2F-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203394.3NP_976328.2  transcription factor E2F7

    See identical proteins and their annotated locations for NP_976328.2

    Status: VALIDATED

    Source sequence(s)
    AC025161, AI380315, AK097677, BC017481, DB159890
    Consensus CDS
    CCDS9016.1
    UniProtKB/Swiss-Prot
    Q96AV8
    Related
    ENSP00000323246.7, ENST00000322886.12
    Conserved Domains (1) summary
    pfam02319
    Location:144211
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    77021251..77065580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537966.2XP_011536268.1  transcription factor E2F7 isoform X1

    Conserved Domains (1) summary
    pfam02319
    Location:144211
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  2. XM_011537969.2XP_011536271.1  transcription factor E2F7 isoform X2

    Conserved Domains (1) summary
    pfam02319
    Location:43110
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
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