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TSPAN19 tetraspanin 19 [ Homo sapiens (human) ]

Gene ID: 144448, updated on 5-Jan-2022

Summary

Official Symbol
TSPAN19provided by HGNC
Official Full Name
tetraspanin 19provided by HGNC
Primary source
HGNC:HGNC:31886
See related
Ensembl:ENSG00000231738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 1.0), lung (RPKM 1.0) and 6 other tissues See more
Orthologs
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Genomic context

See TSPAN19 in Genome Data Viewer
Location:
12q21.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (85014311..85036278, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (85408096..85430055, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 15 Neighboring gene uncharacterized LOC102724680 Neighboring gene Sharpr-MPRA regulatory region 14945 Neighboring gene leucine rich repeats and IQ motif containing 1 Neighboring gene ALX homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ44351

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetraspanin-19
Names
putative tetraspanin-19
tspan-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100917.2NP_001094387.1  tetraspanin-19

    See identical proteins and their annotated locations for NP_001094387.1

    Status: VALIDATED

    Source sequence(s)
    AK126325, BX116902, CB852874
    Consensus CDS
    CCDS44949.1
    UniProtKB/Swiss-Prot
    P0C672
    Related
    ENSP00000433816.2, ENST00000532498.7
    Conserved Domains (2) summary
    cd03160
    Location:107212
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9240
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    85014311..85036278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018863.2XP_016874352.1  tetraspanin-19 isoform X2

    Conserved Domains (2) summary
    cl02781
    Location:107210
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:9238
    Tetraspannin; Tetraspanin family
  2. XM_005268669.4XP_005268726.1  tetraspanin-19 isoform X1

    See identical proteins and their annotated locations for XP_005268726.1

    UniProtKB/Swiss-Prot
    P0C672
    Conserved Domains (2) summary
    cd03160
    Location:107212
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9240
    Tetraspannin; Tetraspanin family
  3. XM_017018862.1XP_016874351.1  tetraspanin-19 isoform X1

    UniProtKB/Swiss-Prot
    P0C672
    Conserved Domains (2) summary
    cd03160
    Location:107212
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9240
    Tetraspannin; Tetraspanin family
  4. XM_017018864.1XP_016874353.1  tetraspanin-19 isoform X3

    Conserved Domains (3) summary
    cl02781
    Location:107198
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:9189
    Tetraspannin; Tetraspanin family
    cl00473
    Location:20109
    BI-1-like; BAX inhibitor (BI)-1/YccA-like protein family

RNA

  1. XR_001748592.1 RNA Sequence

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