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ZNF664 zinc finger protein 664 [ Homo sapiens (human) ]

Gene ID: 144348, updated on 5-Aug-2022

Summary

Official Symbol
ZNF664provided by HGNC
Official Full Name
zinc finger protein 664provided by HGNC
Primary source
HGNC:HGNC:25406
See related
Ensembl:ENSG00000179195 MIM:617890; AllianceGenome:HGNC:25406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFOC1; ZNF176
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 67.7), small intestine (RPKM 46.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF664 in Genome Data Viewer
Location:
12q24.31
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (123973215..124015427)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (123974731..124016943)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124457762..124499974)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 10 Neighboring gene uncharacterized LOC124903043 Neighboring gene ZNF664-RFLNA readthrough Neighboring gene coiled-coil domain containing 92 Neighboring gene refilin A Neighboring gene microRNA 6880 Neighboring gene nuclear receptor corepressor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study identifies new disease loci for isolated clubfoot.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF664-RFLNA

Readthrough gene: ZNF664-RFLNA, Included gene: RFLNA

Homology

Clone Names

  • MGC126579, DKFZp761B128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 664
Names
zinc finger Organ of Corti 1
zinc finger protein 176
zinc finger protein from organ of Corti

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204298.2NP_001191227.1  zinc finger protein 664

    See identical proteins and their annotated locations for NP_001191227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC068790, BC051696, BQ185193, BX647762, DA328413
    Consensus CDS
    CCDS9257.1
    UniProtKB/Swiss-Prot
    Q3ZCQ7, Q8N3J9
    UniProtKB/TrEMBL
    A0A024RBR7
    Related
    ENSP00000376205.3, ENST00000392404.7
    Conserved Domains (3) summary
    COG5048
    Location:94256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:7497
    zf-H2C2_2; Zinc-finger double domain
  2. NM_152437.3NP_689650.1  zinc finger protein 664

    See identical proteins and their annotated locations for NP_689650.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC068790, AK056034, BC051696, BQ185193, BX647762, DA304849
    Consensus CDS
    CCDS9257.1
    UniProtKB/Swiss-Prot
    Q3ZCQ7, Q8N3J9
    UniProtKB/TrEMBL
    A0A024RBR7
    Related
    ENSP00000337320.4, ENST00000337815.9
    Conserved Domains (3) summary
    COG5048
    Location:94256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:7497
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    123973215..124015427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    123974731..124016943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)