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GLIPR1L2 GLIPR1 like 2 [ Homo sapiens (human) ]

Gene ID: 144321, updated on 3-Mar-2026
Official Symbol
GLIPR1L2provided by HGNC
Official Full Name
GLIPR1 like 2provided by HGNC
Primary source
HGNC:HGNC:28592
See related
Ensembl:ENSG00000180481 MIM:610394; AllianceGenome:HGNC:28592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Biased expression in testis (RPKM 10.0), ovary (RPKM 1.3) and 3 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See GLIPR1L2 in Genome Data Viewer
Location:
12q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75391089..75432688)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75365673..75407236)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75784869..75826468)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene necdin, MAGE family member pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75734995-75735496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75735497-75735996 Neighboring gene GLIPR1 like 1 Neighboring gene uncharacterized LOC124902968 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:75770264-75770835 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:75784671-75784843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75880921-75881422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75881423-75881922 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene GLI pathogenesis related 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75904602-75905146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75905147-75905690 Neighboring gene KRR1 small subunit processome component

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. Tam M, et al. J Assoc Genet Technol, 2010. PMID 20978342
  2. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Ren C, et al. Genomics, 2006 Aug. PMID 16714093
  3. Protein phosphatase 1α interacting proteins in the human brain. Esteves SL, et al. OMICS, 2012 Jan-Feb. PMID 22321011, Free PMC Article
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, et al. iScience, 2019 Sep 27. PMID 31536960, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC39497

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in sexual reproduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GLIPR1-like protein 2
Names
GLI pathogenesis related 1 like 2
NP_689649.1

Length

  • 253

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270396.2 → NP_001257325.1  GLIPR1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001257325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AA649108, AC121761, BC016749, BX640916
    Consensus CDS
    CCDS58258.1
    UniProtKB/Swiss-Prot
    Q4G1C9, Q6MZS1, Q8N6N0, Q8NA43
    Related
    ENSP00000448248.1, ENST00000550916.6
    Conserved Domains (1) summary
    cd05385
    Location:52 → 195
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

  2. NM_152436.3 → NP_689649.1  GLIPR1-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_689649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon structure in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC121761, BC016749, BC029557
    Consensus CDS
    CCDS9010.1
    UniProtKB/Swiss-Prot
    Q4G1C9
    Related
    ENSP00000317385.4, ENST00000320460.8
    Conserved Domains (1) summary
    cd05385
    Location:52 → 195
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RNA

  1. NR_072995.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA649108, AC121761, BC016749, BX640916

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    75391089..75432688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537949.2 → XP_011536251.1  GLIPR1-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011536251.1

    UniProtKB/Swiss-Prot
    Q4G1C9
    Related
    ENSP00000367963.3, ENST00000378692.7
    Conserved Domains (1) summary
    cl00133
    Location:1 → 88
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

  2. XM_047428339.1 → XP_047284295.1  GLIPR1-like protein 2 isoform X1

  3. XM_047428338.1 → XP_047284294.1  GLIPR1-like protein 2 isoform X1

  4. XM_024448850.2 → XP_024304618.1  GLIPR1-like protein 2 isoform X2

    Conserved Domains (1) summary
    cl00133
    Location:1 → 118
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

  5. XM_047428342.1 → XP_047284298.1  GLIPR1-like protein 2 isoform X1

  6. XM_047428341.1 → XP_047284297.1  GLIPR1-like protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    75365673..75407236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371163.1 → XP_054227138.1  GLIPR1-like protein 2 isoform X1

  2. XM_054371168.1 → XP_054227143.1  GLIPR1-like protein 2 isoform X3

  3. XM_054371164.1 → XP_054227139.1  GLIPR1-like protein 2 isoform X1

  4. XM_054371167.1 → XP_054227142.1  GLIPR1-like protein 2 isoform X2

  5. XM_054371166.1 → XP_054227141.1  GLIPR1-like protein 2 isoform X1

  6. XM_054371165.1 → XP_054227140.1  GLIPR1-like protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G1C9.2 GenPept UniProtKB/Swiss-Prot:Q4G1C9

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