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GLIPR1L2 GLIPR1 like 2 [ Homo sapiens (human) ]

Gene ID: 144321, updated on 1-Aug-2020

Summary

Official Symbol
GLIPR1L2provided by HGNC
Official Full Name
GLIPR1 like 2provided by HGNC
Primary source
HGNC:HGNC:28592
See related
Ensembl:ENSG00000180481 MIM:610394
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Biased expression in testis (RPKM 10.0), ovary (RPKM 1.3) and 3 other tissues See more
Orthologs

Genomic context

See GLIPR1L2 in Genome Data Viewer
Location:
12q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (75391070..75432688)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75784850..75826468)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene necdin, MAGE family member pseudogene Neighboring gene calcyphosine 2 Neighboring gene GLIPR1 like 1 Neighboring gene uncharacterized LOC105369844 Neighboring gene GLI pathogenesis related 1 Neighboring gene KRR1 small subunit processome component homolog Neighboring gene phosphogluconate dehydrogenase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39497

Gene Ontology Provided by GOA

Process Evidence Code Pubs
binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GLIPR1-like protein 2
Names
GLI pathogenesis related 1 like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270396.2NP_001257325.1  GLIPR1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001257325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AA649108, AC121761, BC016749, BX640916
    Consensus CDS
    CCDS58258.1
    UniProtKB/Swiss-Prot
    Q4G1C9
    Related
    ENSP00000448248.1, ENST00000550916.6
    Conserved Domains (1) summary
    cd05385
    Location:52195
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...
  2. NM_152436.2NP_689649.1  GLIPR1-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_689649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon structure in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC121761, BC016749, BC029557
    Consensus CDS
    CCDS9010.1
    UniProtKB/Swiss-Prot
    Q4G1C9
    Related
    ENSP00000317385.4, ENST00000320460.8
    Conserved Domains (1) summary
    cd05385
    Location:52195
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RNA

  1. NR_072995.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA649108, AC121761, BC016749, BX640916

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    75391070..75432688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537949.2XP_011536251.1  GLIPR1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011536251.1

    UniProtKB/Swiss-Prot
    Q4G1C9
    Related
    ENSP00000367963.3, ENST00000378692.7
    Conserved Domains (1) summary
    cl00133
    Location:188
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  2. XM_017018848.1XP_016874337.1  GLIPR1-like protein 2 isoform X1

    Conserved Domains (1) summary
    cl00133
    Location:1118
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  3. XM_017018849.1XP_016874338.1  GLIPR1-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q4G1C9
    Conserved Domains (1) summary
    cl00133
    Location:188
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  4. XM_011537950.2XP_011536252.1  GLIPR1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011536252.1

    UniProtKB/Swiss-Prot
    Q4G1C9
    Conserved Domains (1) summary
    cl00133
    Location:188
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  5. XM_024448850.1XP_024304618.1  GLIPR1-like protein 2 isoform X1

    Conserved Domains (1) summary
    cl00133
    Location:1118
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
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