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Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 14425, updated on 5-Mar-2024

Summary

Official Symbol
Galnt3provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 3provided by MGI
Primary source
MGI:MGI:894695
See related
Ensembl:ENSMUSG00000026994 AllianceGenome:MGI:894695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium ion binding activity; manganese ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study hyperphosphatemic familial tumoral calcinosis. Orthologous to human GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 15.8), colon adult (RPKM 5.6) and 10 other tissues See more
Orthologs
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Genomic context

See Galnt3 in Genome Data Viewer
Location:
2 C1.3; 2 38.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (65913110..65955217, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (66082766..66125056, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04693 Neighboring gene predicted gene, 51432 Neighboring gene cysteine-serine-rich nuclear protein 3 Neighboring gene predicted gene, 52514 Neighboring gene STARR-seq mESC enhancer starr_04694 Neighboring gene STARR-seq mESC enhancer starr_04695 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene STARR-positive B cell enhancer mm9_chr2:66094546-66094847 Neighboring gene sodium channel, voltage-gated, type I, alpha Neighboring gene predicted gene 13630

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 3
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3
galNAc-T3
polypeptide GalNAc transferase 3
pp-GaNTase 3
ppGaNTase-T3
protein-UDP acetylgalactosaminyltransferase 3
NP_056551.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015736.2NP_056551.2  polypeptide N-acetylgalactosaminyltransferase 3

    See identical proteins and their annotated locations for NP_056551.2

    Status: VALIDATED

    Source sequence(s)
    AK019995, AK135489, AL929230, AV274239
    Consensus CDS
    CCDS16075.1
    UniProtKB/Swiss-Prot
    P70419, Q3UXL2, Q80V55
    Related
    ENSMUSP00000028378.4, ENSMUST00000028378.4
    Conserved Domains (4) summary
    cd02510
    Location:188493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:184302
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:507629
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:506627
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    65913110..65955217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_374409.5 RNA Sequence