U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gad2 glutamic acid decarboxylase 2 [ Mus musculus (house mouse) ]

Gene ID: 14417, updated on 1-Mar-2024

Summary

Official Symbol
Gad2provided by MGI
Official Full Name
glutamic acid decarboxylase 2provided by MGI
Primary source
MGI:MGI:95634
See related
Ensembl:ENSMUSG00000026787 AllianceGenome:MGI:95634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAD65; Gad-2; GAD(65); 6330404F12Rik
Summary
Predicted to enable glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in glutamate decarboxylation to succinate. Predicted to act upstream of or within neurotransmitter biosynthetic process. Located in axon; cytoplasm; and synapse. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 14.3), whole brain E14.5 (RPKM 8.4) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gad2 in Genome Data Viewer
Location:
2 A3; 2 15.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22512262..22583889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22621015..22693877)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_03908 Neighboring gene STARR-seq mESC enhancer starr_03909 Neighboring gene myosin IIIA Neighboring gene STARR-seq mESC enhancer starr_03910 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene microRNA 3967 Neighboring gene STARR-seq mESC enhancer starr_03915 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4417 Neighboring gene STARR-seq mESC enhancer starr_03917 Neighboring gene amyloid beta precursor protein binding family B member 1 interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:22661206-22661359 Neighboring gene STARR-positive B cell enhancer ABC_E7796 Neighboring gene STARR-seq mESC enhancer starr_03918 Neighboring gene STARR-seq mESC enhancer starr_03919 Neighboring gene predicted gene, 52503

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (15)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in gamma-aminobutyric acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutamate decarboxylation to succinate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutamate decarboxylation to succinate ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate decarboxylase 2
Names
65 kDa glutamic acid decarboxylase
GAD-65
NP_032104.2
XP_011237325.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008078.2NP_032104.2  glutamate decarboxylase 2

    See identical proteins and their annotated locations for NP_032104.2

    Status: VALIDATED

    Source sequence(s)
    AL928693, BC018380, BQ571205
    Consensus CDS
    CCDS15724.1
    UniProtKB/Swiss-Prot
    O35519, P48320
    UniProtKB/TrEMBL
    Q548L4
    Related
    ENSMUSP00000028123.4, ENSMUST00000028123.4
    Conserved Domains (1) summary
    pfam00282
    Location:138509
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    22512262..22583889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239023.4XP_011237325.1  glutamate decarboxylase 2 isoform X1

    Conserved Domains (1) summary
    cl18945
    Location:138307
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...