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SPINDOC spindlin interactor and repressor of chromatin binding [ Homo sapiens (human) ]

Gene ID: 144097, updated on 6-Nov-2022

Summary

Official Symbol
SPINDOCprovided by HGNC
Official Full Name
spindlin interactor and repressor of chromatin bindingprovided by HGNC
Primary source
HGNC:HGNC:25115
See related
Ensembl:ENSG00000168005 AllianceGenome:HGNC:25115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf84; SPIN-DOC
Summary
Involved in negative regulation of transcription, DNA-templated. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.7), placenta (RPKM 7.2) and 23 other tissues See more
Orthologs
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Genomic context

See SPINDOC in Genome Data Viewer
Location:
11q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63813456..63827716)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63802814..63817075)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63580928..63595188)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger translocation associated Neighboring gene RNA, 7SL, cytoplasmic 596, pseudogene Neighboring gene ATP synthase membrane subunit g pseudogene 1 Neighboring gene microtubule affinity regulating kinase 2 Neighboring gene RNA, U6 small nuclear 1306, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762N0114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
spindlin interactor and repressor of chromatin-binding protein
Names
SPIN1 docking protein
hypothetical protein BC007540
uncharacterized protein C11orf84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138471.3NP_612480.1  spindlin interactor and repressor of chromatin-binding protein

    See identical proteins and their annotated locations for NP_612480.1

    Status: VALIDATED

    Source sequence(s)
    BC002782, HY013538
    Consensus CDS
    CCDS31594.1
    UniProtKB/Swiss-Prot
    Q96IH0, Q9BUA3
    Related
    ENSP00000294244.3, ENST00000294244.9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63813456..63827716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718437.2XP_006718500.1  spindlin interactor and repressor of chromatin-binding protein isoform X2

    Conserved Domains (1) summary
    pfam18658
    Location:70134
    zf-C2H2_12; Zinc-finger C2H2-type
  2. XM_011544770.2XP_011543072.1  spindlin interactor and repressor of chromatin-binding protein isoform X1

    Conserved Domains (1) summary
    pfam18658
    Location:70134
    zf-C2H2_12; Zinc-finger C2H2-type
  3. XM_011544772.2XP_011543074.1  spindlin interactor and repressor of chromatin-binding protein isoform X4

    Conserved Domains (1) summary
    pfam18658
    Location:70134
    zf-C2H2_12; Zinc-finger C2H2-type
  4. XM_011544771.2XP_011543073.1  spindlin interactor and repressor of chromatin-binding protein isoform X3

    Conserved Domains (1) summary
    pfam18658
    Location:70134
    zf-C2H2_12; Zinc-finger C2H2-type
  5. XM_047426423.1XP_047282379.1  spindlin interactor and repressor of chromatin-binding protein isoform X5

  6. XM_047426424.1XP_047282380.1  spindlin interactor and repressor of chromatin-binding protein isoform X7

  7. XM_005273782.4XP_005273839.1  spindlin interactor and repressor of chromatin-binding protein isoform X6

    Conserved Domains (1) summary
    pfam18658
    Location:70134
    zf-C2H2_12; Zinc-finger C2H2-type
  8. XM_047426425.1XP_047282381.1  spindlin interactor and repressor of chromatin-binding protein isoform X8

RNA

  1. XR_007062453.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63802814..63817075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)