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TTC36 tetratricopeptide repeat domain 36 [ Homo sapiens (human) ]

Gene ID: 143941, updated on 18-Aug-2020

Summary

Official Symbol
TTC36provided by HGNC
Official Full Name
tetratricopeptide repeat domain 36provided by HGNC
Primary source
HGNC:HGNC:33708
See related
Ensembl:ENSG00000172425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBP21
Summary
The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]
Expression
Biased expression in liver (RPKM 51.1), kidney (RPKM 9.2) and 2 other tissues See more
Orthologs

Genomic context

See TTC36 in Genome Data Viewer
Location:
11q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118527474..118530993)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118398210..118401740)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100131626 Neighboring gene ATP synthase membrane subunit g Neighboring gene lysine methyltransferase 2A Neighboring gene uncharacterized LOC101929089 Neighboring gene transmembrane protein 25 Neighboring gene intraflagellar transport 46 Neighboring gene ribosomal protein L5 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetratricopeptide repeat protein 36
Names
HSP70 binding protein 21
TPR repeat protein 36

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080441.4NP_001073910.1  tetratricopeptide repeat protein 36 isoform a

    See identical proteins and their annotated locations for NP_001073910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC146916, EU489483
    Consensus CDS
    CCDS31687.1
    UniProtKB/Swiss-Prot
    A6NLP5
    Related
    ENSP00000307640.4, ENST00000302783.9
    Conserved Domains (2) summary
    sd00006
    Location:5179
    TPR; TPR repeat [structural motif]
    cl26005
    Location:80154
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_001346096.2NP_001333025.1  tetratricopeptide repeat protein 36 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BC171913
    UniProtKB/Swiss-Prot
    A6NLP5
    Conserved Domains (2) summary
    sd00006
    Location:2555
    TPR; TPR repeat [structural motif]
    cl26005
    Location:2195
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  3. NM_001346097.2NP_001333026.1  tetratricopeptide repeat protein 36 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BC171906
    UniProtKB/Swiss-Prot
    A6NLP5
    Conserved Domains (2) summary
    sd00006
    Location:2555
    TPR; TPR repeat [structural motif]
    cl26005
    Location:2195
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  4. NM_001346098.2NP_001333027.1  tetratricopeptide repeat protein 36 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AP000941, AW027968
    UniProtKB/Swiss-Prot
    A6NLP5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118527474..118530993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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