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KBTBD3 kelch repeat and BTB domain containing 3 [ Homo sapiens (human) ]

Gene ID: 143879, updated on 23-Nov-2021

Summary

Official Symbol
KBTBD3provided by HGNC
Official Full Name
kelch repeat and BTB domain containing 3provided by HGNC
Primary source
HGNC:HGNC:22934
See related
Ensembl:ENSG00000182359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKLHD3
Expression
Ubiquitous expression in brain (RPKM 1.9), thyroid (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See KBTBD3 in Genome Data Viewer
Location:
11q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (106046801..106077765, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (105921825..105948074, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene RNA, U6 small nuclear 277, pseudogene Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene long intergenic non-protein coding RNA 2719 Neighboring gene uncharacterized LOC101928535

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30685

General protein information

Preferred Names
kelch repeat and BTB domain-containing protein 3
Names
BTB and kelch domain containing 3
BTB and kelch domain-containing protein 3
epididymis secretory sperm binding protein
kelch repeat and BTB (POZ) domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330359.2NP_001317288.1  kelch repeat and BTB domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001001
    Consensus CDS
    CCDS81621.1
    UniProtKB/TrEMBL
    G3V161
    Related
    ENSP00000431910.1, ENST00000534815.1
    Conserved Domains (4) summary
    PHA03098
    Location:16507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:255310
    Kelch; KELCH repeat [structural motif]
    cd18480
    Location:70151
    BACK_KBTBD3; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    cl38908
    Location:178
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  2. NM_152433.4NP_689646.2  kelch repeat and BTB domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_689646.2

    Status: VALIDATED

    Source sequence(s)
    AP001001, BC117466
    Consensus CDS
    CCDS8334.1
    UniProtKB/Swiss-Prot
    Q8NAB2
    UniProtKB/TrEMBL
    A0A024R3B5
    Related
    ENSP00000436262.1, ENST00000526793.5
    Conserved Domains (4) summary
    PHA03098
    Location:56586
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:334389
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:28157
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    cd18480
    Location:149230
    BACK_KBTBD3; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
  3. NM_198439.3NP_940841.1  kelch repeat and BTB domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_940841.1

    Status: VALIDATED

    Source sequence(s)
    AK289915, AP001001
    Consensus CDS
    CCDS8334.1
    UniProtKB/Swiss-Prot
    Q8NAB2
    UniProtKB/TrEMBL
    A0A024R3B5, A8K1K0
    Related
    ENSP00000432163.1, ENST00000531837.2
    Conserved Domains (4) summary
    PHA03098
    Location:56586
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:334389
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:28157
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    cd18480
    Location:149230
    BACK_KBTBD3; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    106046801..106077765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718767.3XP_006718830.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006718830.1

    UniProtKB/Swiss-Prot
    Q8NAB2
    UniProtKB/TrEMBL
    A0A024R3B5
    Conserved Domains (4) summary
    PHA03098
    Location:56586
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:334389
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:28157
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    cd18480
    Location:149230
    BACK_KBTBD3; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
  2. XM_011542618.2XP_011540920.1  kelch repeat and BTB domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011540920.1

    UniProtKB/Swiss-Prot
    Q8NAB2
    UniProtKB/TrEMBL
    A0A024R3B5
    Conserved Domains (4) summary
    PHA03098
    Location:56586
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:334389
    Kelch; KELCH repeat [structural motif]
    cd18271
    Location:28157
    BTB_POZ_KBTBD3_BKLHD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
    cd18480
    Location:149230
    BACK_KBTBD3; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3)
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